LTB4R2

Entrez Summary: N/A
UniProt Summary: Low-affinity receptor for leukotrienes including leukotriene B4. Mediates chemotaxis of granulocytes and macrophages. The response is mediated via G-proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinities for the leukotrienes is LTB4 > 12-epi-LTB4 > LTB5 > LTB3.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 2/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	1/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	1/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

leukotriene B4 receptor activity
leukotriene receptor activity
leukotriene signaling pathway
keratinocyte migration
galanin receptor activity
negative regulation of adenylate cyclase activity
negative regulation of cyclase activity
negative regulation of lyase activity
regulation of adenylate cyclase activity
G protein-coupled peptide receptor activity
regulation of cyclase activity
regulation of lyase activity
epithelial cell migration
epithelium migration
tissue migration
neuropeptide signaling pathway
ameboidal-type cell migration
inflammatory response
chemotaxis
taxis
negative regulation of catalytic activity
cell migration
localization of cell
cell motility
negative regulation of molecular function
locomotion
G protein-coupled receptor signaling pathway
defense response
integral component of plasma membrane
movement of cell or subcellular component
membrane