LTBP2

Entrez Summary: The protein encoded by this gene belongs to the family of latent transforming growth factor (TGF)-beta binding proteins (LTBP), which are extracellular matrix proteins with multi-domain structure. This protein is the largest member of the LTBP family possessing unique regions and with most similarity to the fibrillins. It has thus been suggested that it may have multiple functions: as a member of the TGF-beta latent complex, as a structural component of microfibrils, and a role in cell adhesion. [provided by RefSeq, Jul 2008].
UniProt Summary: May play an integral structural role in elastic-fiber architectural organization and/or assembly.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

microfibril binding
growth factor binding
cell
transforming growth factor beta receptor signaling pathway
extracellular matrix structural constituent
cellular response to transforming growth factor beta stimulus
protein secretion
establishment of protein localization to extracellular region
response to transforming growth factor beta
protein localization to extracellular region
heparin binding
peptide secretion
transmembrane receptor protein serine/threonine kinase signaling pathway
extracellular matrix
protein targeting
collagen-containing extracellular matrix
supramolecular fiber organization
cellular response to growth factor stimulus
response to growth factor
enzyme linked receptor protein signaling pathway
calcium ion binding
intracellular protein transport
secretion by cell
export from cell
secretion
cellular response to endogenous stimulus
response to endogenous stimulus
protein transport
intracellular transport
peptide transport
amide transport
cellular protein localization
extracellular space
cellular macromolecule localization
establishment of protein localization
establishment of localization in cell
nitrogen compound transport
extracellular region