LTK

Gene Information

Official Symbol: LTK
Official Name: leukocyte receptor tyrosine kinase
Aliases and Previous Symbols: N/A
Entrez ID: 4058
UniProt: P29376
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Receptor with a tyrosine-protein kinase activity. The exact function of this protein is not known. Studies with chimeric proteins (replacing its extracellular region with that of several known growth factor receptors, such as EGFR and CSFIR) demonstrate its ability to promote growth and specifically neurite outgrowth, and cell survival. Signaling appears to involve the PI3 kinase pathway. Involved in regulation of the secretory pathway involving endoplasmic reticulum (ER) export sites (ERESs) and ER to Golgi transport. {ECO:0000269|PubMed:20548102}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 3153
Expression level (log2 read counts): -1.72

Expression Distribution

Pkinase
Pkinase Tyr
Gly rich

positive regulation of striated muscle cell apoptotic process
positive regulation of cardiac muscle cell apoptotic process
positive regulation of muscle cell apoptotic process
phosphatidylinositol 3-kinase signaling
regulation of cardiac muscle cell apoptotic process
regulation of striated muscle cell apoptotic process
transmembrane receptor protein tyrosine kinase activity
regulation of muscle cell apoptotic process
cellular response to retinoic acid
phosphatidylinositol-mediated signaling
inositol lipid-mediated signaling
protein tyrosine kinase activity
response to retinoic acid
peptidyl-tyrosine phosphorylation
peptidyl-tyrosine modification
receptor complex
cellular response to acid chemical
protein kinase activity
positive regulation of neuron projection development
response to acid chemical
positive regulation of neuron differentiation
positive regulation of cell projection organization
positive regulation of neurogenesis
regulation of neuron projection development
transmembrane receptor protein tyrosine kinase signaling pathway
cellular response to lipid
positive regulation of nervous system development
positive regulation of cell development
cell population proliferation
positive regulation of apoptotic process
positive regulation of programmed cell death
regulation of neuron differentiation
regulation of plasma membrane bounded cell projection organization
positive regulation of cell death
regulation of cell projection organization
enzyme linked receptor protein signaling pathway
regulation of neurogenesis
response to lipid
peptidyl-amino acid modification
negative regulation of apoptotic process