LYPD1

Entrez Summary: N/A
UniProt Summary: Believed to act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro increases receptor desensitization and decreases affinity for ACh of alpha- 4:beta-2-containing nAChRs. May play a role in the intracellular trafficking of alpha-4:beta-2 and alpha-7-containing nAChRs and may inhibit their expression at the cell surface. May be involved in the control of anxiety. {ECO:0000250|UniProtKB:Q8BLC3}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

acetylcholine receptor inhibitor activity
acetylcholine receptor binding
negative regulation of protein localization to plasma membrane
negative regulation of protein localization to cell periphery
synaptic transmission, cholinergic
behavioral fear response
acetylcholine receptor signaling pathway
negative regulation of protein localization to membrane
behavioral defense response
response to acetylcholine
cellular response to acetylcholine
fear response
postsynaptic signal transduction
response to nicotine
negative regulation of signaling receptor activity
multicellular organismal response to stress
signal transduction involved in cellular response to ammonium ion
regulation of protein localization to plasma membrane
anchored component of membrane
negative regulation of cellular protein localization
regulation of protein localization to cell periphery
cellular response to ammonium ion
regulation of signaling receptor activity
response to ammonium ion
regulation of protein localization to membrane
cellular response to drug
chemical synaptic transmission
anterograde trans-synaptic signaling
trans-synaptic signaling
synaptic signaling
response to toxic substance
regulation of cellular protein localization
behavior
cellular response to hormone stimulus
cellular response to nitrogen compound
response to hormone
regulation of cellular localization
response to drug
regulation of protein localization
cellular response to oxygen-containing compound