LYPD6

Entrez Summary: N/A
UniProt Summary: Acts as a modulator of nicotinic acetylcholine receptors (nAChRs) function in the brain. Inhibits nicotine-induced Ca(2+) influx through nAChRs (PubMed:27344019). Acts as a positive regulator of Wnt/beta-catenin signaling (By similarity). {ECO:0000250|UniProtKB:Q66IA6, ECO:0000269|PubMed:27344019}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

acetylcholine receptor inhibitor activity
acetylcholine receptor regulator activity
negative regulation of signaling receptor activity
regulation of neurotransmitter receptor activity
anchored component of membrane
positive regulation of canonical Wnt signaling pathway
regulation of signaling receptor activity
positive regulation of Wnt signaling pathway
membrane raft
synapse
regulation of canonical Wnt signaling pathway
neuron projection
regulation of Wnt signaling pathway
cell junction
negative regulation of molecular function
positive regulation of signal transduction
positive regulation of cell communication
positive regulation of signaling
extracellular region