LYST [The Human Chemical-Genetic Interaction Map Project]

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======= LYST =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: LYST
  * **<color #00a2e8>Official Name</color>**: lysosomal trafficking regulator
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1130|1130]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q99698|Q99698]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=LYST&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20LYST|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606897|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a protein that regulates intracellular protein trafficking in endosomes, and may be involved in pigmentation. Mutations in this gene are associated with Chediak-Higashi syndrome, a lysosomal storage disorder. Alternative splicing results in multiple transcript variants, though the full-length nature of some of these variants has not been determined. [provided by RefSeq, Apr 2013]. 
  * **<color #00a2e8>UniProt Summary</color>**:  May be required for sorting endosomal resident proteins into late multivesicular endosomes by a mechanism involving microtubules.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Beach|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|mast cell secretory granule organization|
|endosome to lysosome transport via multivesicular body sorting pathway|
|defense response to protozoan|
|melanosome organization|
|response to protozoan|
|pigment granule organization|
|endosome transport via multivesicular body sorting pathway|
|natural killer cell mediated cytotoxicity|
|natural killer cell mediated immunity|
|multivesicular body sorting pathway|
|secretory granule organization|
|leukocyte mediated cytotoxicity|
|cellular pigmentation|
|endosome to lysosome transport|
|lytic vacuole organization|
|lysosome organization|
|cell killing|
|pigmentation|
|lysosomal transport|
|vacuole organization|
|vacuolar transport|
|leukocyte chemotaxis|
|microtubule cytoskeleton|
|defense response to virus|
|cell chemotaxis|
|endosomal transport|
|lymphocyte mediated immunity|
|response to virus|
|vesicle organization|
|defense response to bacterium|
|leukocyte migration|
|endomembrane system organization|
|chemotaxis|
|taxis|
|response to bacterium|
|innate immune response|
|leukocyte mediated immunity|
|defense response to other organism|
|cell migration|
|localization of cell|
|cell motility|
|immune effector process|
|response to other organism|
|response to external biotic stimulus|
|locomotion|
|response to biotic stimulus|
|defense response|
|protein transport|
|intracellular transport|
|peptide transport|
|movement of cell or subcellular component|
|amide transport|
|establishment of protein localization|
|establishment of localization in cell|
|nitrogen compound transport|
|immune response|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp22|MLN-4924 2μM R00 exp22]]|2.32|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5891
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.99 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='LYST Expression in NALM6 Cells: 3.99'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>