LYST
Gene Information
- Official Symbol: LYST
- Official Name: lysosomal trafficking regulator
- Aliases and Previous Symbols: N/A
- Entrez ID: 1130
- UniProt: Q99698
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a protein that regulates intracellular protein trafficking in endosomes, and may be involved in pigmentation. Mutations in this gene are associated with Chediak-Higashi syndrome, a lysosomal storage disorder. Alternative splicing results in multiple transcript variants, though the full-length nature of some of these variants has not been determined. [provided by RefSeq, Apr 2013].
- UniProt Summary: May be required for sorting endosomal resident proteins into late multivesicular endosomes by a mechanism involving microtubules.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 5891
- Expression level (log2 read counts): 3.99
LYST Expression in NALM6 Cells: 3.99
