LYVE1

Entrez Summary: N/A
UniProt Summary: Ligand-specific transporter trafficking between intracellular organelles (TGN) and the plasma membrane. Plays a role in autocrine regulation of cell growth mediated by growth regulators containing cell surface retention sequence binding (CRS). May act as a hyaluronan (HA) transporter, either mediating its uptake for catabolism within lymphatic endothelial cells themselves, or its transport into the lumen of afferent lymphatic vessels for subsequent re-uptake and degradation in lymph nodes. {ECO:0000269|PubMed:10037799}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

hyaluronan catabolic process
hyaluronic acid binding
hyaluronan metabolic process
glycosaminoglycan catabolic process
aminoglycan catabolic process
mucopolysaccharide metabolic process
cell-matrix adhesion
transmembrane signaling receptor activity
glycosaminoglycan metabolic process
aminoglycan metabolic process
cell-substrate adhesion
carbohydrate derivative catabolic process
signaling receptor activity
carboxylic acid catabolic process
organic acid catabolic process
small molecule catabolic process
response to wounding
carboxylic acid metabolic process
cell adhesion
biological adhesion
oxoacid metabolic process
organic acid metabolic process
carbohydrate derivative metabolic process
macromolecule catabolic process
organonitrogen compound catabolic process
integral component of plasma membrane
small molecule metabolic process
organic substance catabolic process
cellular catabolic process
membrane