LZTS1

Entrez Summary: This gene encodes a tumor suppressor protein that is ubiquitously expressed in normal tissues. In uveal melanomas, expression of this protein is silenced in rapidly metastasizing and metastatic tumor cells but has normal expression in slowly metastasizing or nonmetastasizing tumor cells. This protein may have a role in cell-cycle control by interacting with the Cdk1/cyclinB1 complex. This gene is located on chromosomal region 8p22. Loss of heterozygosity (LOH) in the 8p arm is a common characteristic of many types of cancer. [provided by RefSeq, Nov 2009].
UniProt Summary: Involved in the regulation of cell growth. May stabilize the active CDC2-cyclin B1 complex and thereby contribute to the regulation of the cell cycle and the prevention of uncontrolled cell proliferation. May act as a tumor suppressor. {ECO:0000269|PubMed:10097140, ECO:0000269|PubMed:11464283, ECO:0000269|PubMed:11504921}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

negative regulation of macroautophagy
dendritic shaft
cell body
negative regulation of autophagy
regulation of dendrite morphogenesis
dendritic spine
regulation of dendrite development
regulation of macroautophagy
regulation of synaptic plasticity
postsynaptic membrane
microtubule binding
negative regulation of cellular catabolic process
postsynaptic density
mitotic cell cycle phase transition
cell cycle phase transition
regulation of cell morphogenesis involved in differentiation
negative regulation of catabolic process
apical plasma membrane
regulation of autophagy
modulation of chemical synaptic transmission
regulation of trans-synaptic signaling
regulation of cell morphogenesis
regulation of neuron projection development
cell junction
mitotic cell cycle process
transcription, DNA-templated
nucleic acid-templated transcription
RNA biosynthetic process
regulation of neuron differentiation
DNA-binding transcription factor activity
mitotic cell cycle
regulation of plasma membrane bounded cell projection organization
regulation of cell projection organization
regulation of neurogenesis
regulation of cellular catabolic process
regulation of nervous system development
regulation of cell development
regulation of catabolic process
cell cycle process
regulation of anatomical structure morphogenesis