MAFG

Entrez Summary: N/A
UniProt Summary: Since they lack a putative transactivation domain, the small Mafs behave as transcriptional repressors when they dimerize among themselves (PubMed:11154691). However, they seem to serve as transcriptional activators by dimerizing with other (usually larger) basic-zipper proteins, such as NFE2, NFE2L1 and NFE2L2, and recruiting them to specific DNA-binding sites (PubMed:8932385, PubMed:9421508, PubMed:11154691). Small Maf proteins heterodimerize with Fos and may act as competitive repressors of the NFE2L2 transcription factor (PubMed:11154691). Transcription factor, component of erythroid-specific transcription factor NFE2L2 (PubMed:11154691). Activates globin gene expression when associated with NFE2L2 (PubMed:11154691). May be involved in signal transduction of extracellular H(+) (By similarity). {ECO:0000250|UniProtKB:Q76MX4, ECO:0000269|PubMed:11154691, ECO:0000269|PubMed:8932385, ECO:0000269|PubMed:9421508}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

regulation of epidermal cell differentiation
regulation of epidermis development
regulation of cellular pH
regulation of pH
cellular monovalent inorganic cation homeostasis
monovalent inorganic cation homeostasis
regulation of epithelial cell differentiation
adult behavior
blood coagulation
coagulation
hemostasis
in utero embryonic development
sequence-specific DNA binding
DNA-binding transcription activator activity, RNA polymerase II-specific
wound healing
protein heterodimerization activity
regulation of body fluid levels
RNA polymerase II proximal promoter sequence-specific DNA binding
response to wounding
behavior
cellular cation homeostasis
chordate embryonic development
cellular ion homeostasis
embryo development ending in birth or egg hatching
DNA-binding transcription factor activity
cation homeostasis
inorganic ion homeostasis
cellular chemical homeostasis
ion homeostasis
cellular homeostasis
embryo development
chemical homeostasis
positive regulation of transcription by RNA polymerase II
positive regulation of transcription, DNA-templated
DNA-binding transcription factor activity, RNA polymerase II-specific
regulation of cell population proliferation
positive regulation of nucleic acid-templated transcription
positive regulation of RNA biosynthetic process
homeostatic process
positive regulation of RNA metabolic process