MAGEF1

Gene Information

Official Symbol: MAGEF1
Official Name: MAGE family member F1
Aliases and Previous Symbols: N/A
Entrez ID: 64110
UniProt: Q9HAY2
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. {ECO:0000269|PubMed:20864041}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 17251
Expression level (log2 read counts): 2.62

Expression Distribution

protein maturation by iron-sulfur cluster transfer
negative regulation of double-strand break repair via homologous recombination
negative regulation of double-strand break repair
negative regulation of DNA repair
negative regulation of DNA recombination
regulation of double-strand break repair via homologous recombination
regulation of double-strand break repair
negative regulation of response to DNA damage stimulus
positive regulation of ubiquitin-dependent protein catabolic process
regulation of DNA recombination
positive regulation of proteolysis involved in cellular protein catabolic process
negative regulation of DNA metabolic process
regulation of DNA repair
positive regulation of cellular protein catabolic process
regulation of ubiquitin-dependent protein catabolic process
positive regulation of protein catabolic process
regulation of proteolysis involved in cellular protein catabolic process
regulation of response to DNA damage stimulus
protein maturation
regulation of cellular protein catabolic process
regulation of DNA metabolic process
positive regulation of proteolysis
positive regulation of cellular catabolic process
regulation of protein catabolic process
positive regulation of catabolic process
protein ubiquitination
regulation of proteolysis
regulation of cellular response to stress
protein modification by small protein conjugation
regulation of cellular catabolic process
protein modification by small protein conjugation or removal
regulation of catabolic process
negative regulation of nucleobase-containing compound metabolic process
regulation of response to stress
positive regulation of cellular protein metabolic process
negative regulation of response to stimulus
positive regulation of protein metabolic process
gene expression