MALT1 [The Human Chemical-Genetic Interaction Map Project]

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======= MALT1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MALT1
  * **<color #00a2e8>Official Name</color>**: MALT1 paracaspase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10892|10892]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UDY8|Q9UDY8]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MALT1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MALT1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604860|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene has been found to be recurrently rearranged in chromosomal translocation with two other genes - baculoviral IAP repeat-containing protein 3 (also known as apoptosis inhibitor 2) and immunoglobulin heavy chain locus - in mucosa-associated lymphoid tissue lymphomas. The protein encoded by this gene may play a role in NF-kappaB activation. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Enhances BCL10-induced activation of NF-kappa-B. Involved in nuclear export of BCL10. Binds to TRAF6, inducing TRAF6 oligomerization and activation of its ligase activity. Has ubiquitin ligase activity. MALT1-dependent BCL10 cleavage plays an important role in T-cell antigen receptor-induced integrin adhesion. {ECO:0000269|PubMed:11262391, ECO:0000269|PubMed:14695475, ECO:0000269|PubMed:18264101}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|ig|
|I-set|
|Peptidase C14|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|CBM complex|
|B-1 B cell differentiation|
|kinase activator activity|
|positive regulation of T-helper 17 cell differentiation|
|positive regulation of T-helper 17 type immune response|
|regulation of T-helper 17 cell differentiation|
|activation of NF-kappaB-inducing kinase activity|
|positive regulation of T cell cytokine production|
|regulation of T-helper 17 type immune response|
|positive regulation of T-helper cell differentiation|
|mature B cell differentiation|
|positive regulation of CD4-positive, alpha-beta T cell differentiation|
|positive regulation of interleukin-2 production|
|regulation of T cell cytokine production|
|lipopolysaccharide-mediated signaling pathway|
|positive regulation of CD4-positive, alpha-beta T cell activation|
|regulation of T-helper cell differentiation|
|T cell proliferation|
|regulation of T cell receptor signaling pathway|
|regulation of CD4-positive, alpha-beta T cell differentiation|
|positive regulation of alpha-beta T cell differentiation|
|positive regulation of T cell mediated immunity|
|response to fungus|
|positive regulation of interleukin-1 beta production|
|positive regulation of cytokine production involved in immune response|
|regulation of interleukin-2 production|
|protein self-association|
|positive regulation of interleukin-1 production|
|positive regulation of alpha-beta T cell activation|
|regulation of CD4-positive, alpha-beta T cell activation|
|regulation of alpha-beta T cell differentiation|
|regulation of antigen receptor-mediated signaling pathway|
|regulation of T cell mediated immunity|
|positive regulation of NIK/NF-kappaB signaling|
|NIK/NF-kappaB signaling|
|regulation of interleukin-1 beta production|
|peptidase activity|
|positive regulation of T cell differentiation|
|lymphocyte proliferation|
|regulation of cytokine production involved in immune response|
|mononuclear cell proliferation|
|cysteine-type endopeptidase activity|
|regulation of alpha-beta T cell activation|
|positive regulation of lymphocyte differentiation|
|regulation of interleukin-1 production|
|positive regulation of production of molecular mediator of immune response|
|leukocyte proliferation|
|positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|protease binding|
|positive regulation of lymphocyte mediated immunity|
|positive regulation of adaptive immune response|
|B cell differentiation|
|regulation of NIK/NF-kappaB signaling|
|stimulatory C-type lectin receptor signaling pathway|
|positive regulation of protein ubiquitination|
|innate immune response activating cell surface receptor signaling pathway|
|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|fibrillar center|
|positive regulation of leukocyte mediated immunity|
|positive regulation of protein modification by small protein conjugation or removal|
|regulation of T cell differentiation|
|regulation of production of molecular mediator of immune response|
|regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|positive regulation of leukocyte differentiation|
|regulation of lymphocyte mediated immunity|
|positive regulation of cysteine-type endopeptidase activity|
|positive regulation of NF-kappaB transcription factor activity|
|B cell activation|
|nuclear export|
|regulation of adaptive immune response|
|regulation of lymphocyte differentiation|
|positive regulation of endopeptidase activity|
|Fc-epsilon receptor signaling pathway|
|T cell receptor signaling pathway|
|cellular response to lipopolysaccharide|
|positive regulation of I-kappaB kinase/NF-kappaB signaling|
|positive regulation of hemopoiesis|
|positive regulation of peptidase activity|
|cellular response to molecule of bacterial origin|
|regulation of protein ubiquitination|
|positive regulation of T cell activation|
|regulation of leukocyte mediated immunity|
|cellular response to biotic stimulus|
|regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|positive regulation of leukocyte cell-cell adhesion|
|positive regulation of immune effector process|
|regulation of protein modification by small protein conjugation or removal|
|innate immune response-activating signal transduction|
|T cell activation|
|regulation of I-kappaB kinase/NF-kappaB signaling|
|lymphocyte differentiation|
|Fc receptor signaling pathway|
|regulation of cysteine-type endopeptidase activity|
|ubiquitin-protein transferase activity|
|positive regulation of cell-cell adhesion|
|activation of innate immune response|
|positive regulation of DNA-binding transcription factor activity|
|nucleocytoplasmic transport|
|nuclear transport|
|regulation of leukocyte differentiation|
|antigen receptor-mediated signaling pathway|
|regulation of leukocyte cell-cell adhesion|
|response to lipopolysaccharide|
|regulation of T cell activation|
|response to molecule of bacterial origin|
|activation of protein kinase activity|
|leukocyte differentiation|
|positive regulation of innate immune response|
|positive regulation of proteolysis|
|positive regulation of lymphocyte activation|
|positive regulation of response to biotic stimulus|
|lymphocyte activation|
|regulation of cell-cell adhesion|
|positive regulation of leukocyte activation|
|positive regulation of cell adhesion|
|positive regulation of cell activation|
|regulation of endopeptidase activity|
|regulation of DNA-binding transcription factor activity|
|regulation of peptidase activity|
|positive regulation of cytokine production|
|immune response-activating cell surface receptor signaling pathway|
|regulation of hemopoiesis|
|regulation of innate immune response|
|regulation of immune effector process|
|positive regulation of defense response|
|immune response-regulating cell surface receptor signaling pathway|
|positive regulation of multi-organism process|
|regulation of lymphocyte activation|
|protein complex oligomerization|
|cellular response to lipid|
|regulation of response to biotic stimulus|
|positive regulation of protein kinase activity|
|cell population proliferation|
|hemopoiesis|
|immune response-activating signal transduction|
|positive regulation of kinase activity|
|protein-containing complex|
|immune response-regulating signaling pathway|
|regulation of leukocyte activation|
|positive regulation of response to external stimulus|
|hematopoietic or lymphoid organ development|
|activation of immune response|
|regulation of cell activation|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|immune system development|
|positive regulation of transferase activity|
|regulation of cell adhesion|
|protein ubiquitination|
|response to bacterium|
|regulation of cytokine production|
|positive regulation of cell death|
|perinuclear region of cytoplasm|
|regulation of proteolysis|
|regulation of defense response|
|innate immune response|
|positive regulation of hydrolase activity|
|protein modification by small protein conjugation|
|regulation of multi-organism process|
|regulation of protein kinase activity|
|response to lipid|
|nucleolus|
|positive regulation of immune response|
|regulation of kinase activity|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|leukocyte activation|
|defense response to other organism|
|positive regulation of cell differentiation|
|regulation of transferase activity|
|protein modification by small protein conjugation or removal|
|negative regulation of cell death|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|cellular response to oxygen-containing compound|
|positive regulation of phosphorylation|
|identical protein binding|
|cell activation|
|regulation of response to external stimulus|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|positive regulation of immune system process|
|regulation of immune response|
|positive regulation of protein modification process|
|proteolysis|
|regulation of hydrolase activity|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|positive regulation of developmental process|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|regulation of response to stress|
|intracellular transport|
|regulation of apoptotic process|
|response to oxygen-containing compound|
|protein-containing complex assembly|
|regulation of programmed cell death|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|regulation of immune system process|
|positive regulation of signal transduction|
|regulation of cell death|
|intracellular signal transduction|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|establishment of localization in cell|
|regulation of protein modification process|
|protein-containing complex subunit organization|
|immune response|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|1.84|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15957
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.2 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MALT1 Expression in NALM6 Cells: 6.2'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>