MALT1
Gene Information
- Official Symbol: MALT1
- Official Name: MALT1 paracaspase
- Aliases and Previous Symbols: N/A
- Entrez ID: 10892
- UniProt: Q9UDY8
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene has been found to be recurrently rearranged in chromosomal translocation with two other genes - baculoviral IAP repeat-containing protein 3 (also known as apoptosis inhibitor 2) and immunoglobulin heavy chain locus - in mucosa-associated lymphoid tissue lymphomas. The protein encoded by this gene may play a role in NF-kappaB activation. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008].
- UniProt Summary: Enhances BCL10-induced activation of NF-kappa-B. Involved in nuclear export of BCL10. Binds to TRAF6, inducing TRAF6 oligomerization and activation of its ligase activity. Has ubiquitin ligase activity. MALT1-dependent BCL10 cleavage plays an important role in T-cell antigen receptor-induced integrin adhesion. {ECO:0000269|PubMed:11262391, ECO:0000269|PubMed:14695475, ECO:0000269|PubMed:18264101}.
Pfam Domains GO Terms
Pfam Domains
| ig |
| I-set |
| Peptidase C14 |
GO Terms
| CBM complex |
| B-1 B cell differentiation |
| kinase activator activity |
| positive regulation of T-helper 17 cell differentiation |
| positive regulation of T-helper 17 type immune response |
| regulation of T-helper 17 cell differentiation |
| activation of NF-kappaB-inducing kinase activity |
| positive regulation of T cell cytokine production |
| regulation of T-helper 17 type immune response |
| positive regulation of T-helper cell differentiation |
| mature B cell differentiation |
| positive regulation of CD4-positive, alpha-beta T cell differentiation |
| positive regulation of interleukin-2 production |
| regulation of T cell cytokine production |
| lipopolysaccharide-mediated signaling pathway |
| positive regulation of CD4-positive, alpha-beta T cell activation |
| regulation of T-helper cell differentiation |
| T cell proliferation |
| regulation of T cell receptor signaling pathway |
| regulation of CD4-positive, alpha-beta T cell differentiation |
| positive regulation of alpha-beta T cell differentiation |
| positive regulation of T cell mediated immunity |
| response to fungus |
| positive regulation of interleukin-1 beta production |
| positive regulation of cytokine production involved in immune response |
| regulation of interleukin-2 production |
| protein self-association |
| positive regulation of interleukin-1 production |
| positive regulation of alpha-beta T cell activation |
| regulation of CD4-positive, alpha-beta T cell activation |
| regulation of alpha-beta T cell differentiation |
| regulation of antigen receptor-mediated signaling pathway |
| regulation of T cell mediated immunity |
| positive regulation of NIK/NF-kappaB signaling |
| NIK/NF-kappaB signaling |
| regulation of interleukin-1 beta production |
| peptidase activity |
| positive regulation of T cell differentiation |
| lymphocyte proliferation |
| regulation of cytokine production involved in immune response |
| mononuclear cell proliferation |
| cysteine-type endopeptidase activity |
| regulation of alpha-beta T cell activation |
| positive regulation of lymphocyte differentiation |
| regulation of interleukin-1 production |
| positive regulation of production of molecular mediator of immune response |
| leukocyte proliferation |
| positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains |
| protease binding |
| positive regulation of lymphocyte mediated immunity |
| positive regulation of adaptive immune response |
| B cell differentiation |
| regulation of NIK/NF-kappaB signaling |
| stimulatory C-type lectin receptor signaling pathway |
| positive regulation of protein ubiquitination |
| innate immune response activating cell surface receptor signaling pathway |
| positive regulation of cysteine-type endopeptidase activity involved in apoptotic process |
| fibrillar center |
| positive regulation of leukocyte mediated immunity |
| positive regulation of protein modification by small protein conjugation or removal |
| regulation of T cell differentiation |
| regulation of production of molecular mediator of immune response |
| regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains |
| positive regulation of leukocyte differentiation |
| regulation of lymphocyte mediated immunity |
| positive regulation of cysteine-type endopeptidase activity |
| positive regulation of NF-kappaB transcription factor activity |
| B cell activation |
| nuclear export |
| regulation of adaptive immune response |
| regulation of lymphocyte differentiation |
| positive regulation of endopeptidase activity |
| Fc-epsilon receptor signaling pathway |
| T cell receptor signaling pathway |
| cellular response to lipopolysaccharide |
| positive regulation of I-kappaB kinase/NF-kappaB signaling |
| positive regulation of hemopoiesis |
| positive regulation of peptidase activity |
| cellular response to molecule of bacterial origin |
| regulation of protein ubiquitination |
| positive regulation of T cell activation |
| regulation of leukocyte mediated immunity |
| cellular response to biotic stimulus |
| regulation of cysteine-type endopeptidase activity involved in apoptotic process |
| positive regulation of leukocyte cell-cell adhesion |
| positive regulation of immune effector process |
| regulation of protein modification by small protein conjugation or removal |
| innate immune response-activating signal transduction |
| T cell activation |
| regulation of I-kappaB kinase/NF-kappaB signaling |
| lymphocyte differentiation |
| Fc receptor signaling pathway |
| regulation of cysteine-type endopeptidase activity |
| ubiquitin-protein transferase activity |
| positive regulation of cell-cell adhesion |
| activation of innate immune response |
| positive regulation of DNA-binding transcription factor activity |
| nucleocytoplasmic transport |
| nuclear transport |
| regulation of leukocyte differentiation |
| antigen receptor-mediated signaling pathway |
| regulation of leukocyte cell-cell adhesion |
| response to lipopolysaccharide |
| regulation of T cell activation |
| response to molecule of bacterial origin |
| activation of protein kinase activity |
| leukocyte differentiation |
| positive regulation of innate immune response |
| positive regulation of proteolysis |
| positive regulation of lymphocyte activation |
| positive regulation of response to biotic stimulus |
| lymphocyte activation |
| regulation of cell-cell adhesion |
| positive regulation of leukocyte activation |
| positive regulation of cell adhesion |
| positive regulation of cell activation |
| regulation of endopeptidase activity |
| regulation of DNA-binding transcription factor activity |
| regulation of peptidase activity |
| positive regulation of cytokine production |
| immune response-activating cell surface receptor signaling pathway |
| regulation of hemopoiesis |
| regulation of innate immune response |
| regulation of immune effector process |
| positive regulation of defense response |
| immune response-regulating cell surface receptor signaling pathway |
| positive regulation of multi-organism process |
| regulation of lymphocyte activation |
| protein complex oligomerization |
| cellular response to lipid |
| regulation of response to biotic stimulus |
| positive regulation of protein kinase activity |
| cell population proliferation |
| hemopoiesis |
| immune response-activating signal transduction |
| positive regulation of kinase activity |
| protein-containing complex |
| immune response-regulating signaling pathway |
| regulation of leukocyte activation |
| positive regulation of response to external stimulus |
| hematopoietic or lymphoid organ development |
| activation of immune response |
| regulation of cell activation |
| positive regulation of apoptotic process |
| positive regulation of programmed cell death |
| immune system development |
| positive regulation of transferase activity |
| regulation of cell adhesion |
| protein ubiquitination |
| response to bacterium |
| regulation of cytokine production |
| positive regulation of cell death |
| perinuclear region of cytoplasm |
| regulation of proteolysis |
| regulation of defense response |
| innate immune response |
| positive regulation of hydrolase activity |
| protein modification by small protein conjugation |
| regulation of multi-organism process |
| regulation of protein kinase activity |
| response to lipid |
| nucleolus |
| positive regulation of immune response |
| regulation of kinase activity |
| negative regulation of apoptotic process |
| negative regulation of programmed cell death |
| leukocyte activation |
| defense response to other organism |
| positive regulation of cell differentiation |
| regulation of transferase activity |
| protein modification by small protein conjugation or removal |
| negative regulation of cell death |
| positive regulation of protein phosphorylation |
| positive regulation of intracellular signal transduction |
| cellular response to oxygen-containing compound |
| positive regulation of phosphorylation |
| identical protein binding |
| cell activation |
| regulation of response to external stimulus |
| positive regulation of phosphorus metabolic process |
| positive regulation of phosphate metabolic process |
| positive regulation of immune system process |
| regulation of immune response |
| positive regulation of protein modification process |
| proteolysis |
| regulation of hydrolase activity |
| response to other organism |
| response to external biotic stimulus |
| response to biotic stimulus |
| defense response |
| positive regulation of developmental process |
| positive regulation of catalytic activity |
| regulation of protein phosphorylation |
| regulation of response to stress |
| intracellular transport |
| regulation of apoptotic process |
| response to oxygen-containing compound |
| protein-containing complex assembly |
| regulation of programmed cell death |
| regulation of phosphorylation |
| positive regulation of cellular protein metabolic process |
| regulation of immune system process |
| positive regulation of signal transduction |
| regulation of cell death |
| intracellular signal transduction |
| positive regulation of protein metabolic process |
| positive regulation of multicellular organismal process |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of cell differentiation |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| establishment of localization in cell |
| regulation of protein modification process |
| protein-containing complex subunit organization |
| immune response |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Oligomycin-A 2μM R00 exp25 | 1.84 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 15957
- Expression level (log2 read counts): 6.2
Expression Distribution
MALT1 Expression in NALM6 Cells: 6.2
