MAP1A [The Human Chemical-Genetic Interaction Map Project]

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======= MAP1A =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MAP1A
  * **<color #00a2e8>Official Name</color>**: microtubule associated protein 1A
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4130|4130]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P78559|P78559]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MAP1A&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MAP1A|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600178|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Structural protein involved in the filamentous cross- bridging between microtubules and other skeletal elements.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|primary dendrite|
|retrograde axonal protein transport|
|dendritic branch|
|dendritic microtubule|
|regulation of protein localization to microtubule|
|negative regulation of protein localization to microtubule|
|voluntary musculoskeletal movement|
|anterograde axonal protein transport|
|protein localization to presynapse|
|neuron projection maintenance|
|axo-dendritic protein transport|
|cytoskeletal adaptor activity|
|positive regulation of protein localization to cell surface|
|retrograde axonal transport|
|axon initial segment|
|regulation of microtubule depolymerization|
|microtubule associated complex|
|neuron cellular homeostasis|
|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|
|dendritic shaft|
|regulation of protein localization to cell surface|
|neuron projection organization|
|musculoskeletal movement|
|multicellular organismal movement|
|anterograde axonal transport|
|tau protein binding|
|negative regulation of ubiquitin-dependent protein catabolic process|
|tubulin binding|
|axonal transport|
|negative regulation of proteasomal protein catabolic process|
|axon cytoplasm|
|protein localization to synapse|
|axo-dendritic transport|
|protein transport along microtubule|
|microtubule-based protein transport|
|negative regulation of proteolysis involved in cellular protein catabolic process|
|associative learning|
|regulation of microtubule polymerization or depolymerization|
|regulation of protein depolymerization|
|negative regulation of cellular protein catabolic process|
|cell projection|
|dendrite development|
|negative regulation of cellular protein localization|
|regulation of protein complex disassembly|
|memory|
|regulation of proteasomal ubiquitin-dependent protein catabolic process|
|negative regulation of protein catabolic process|
|learning|
|regulation of ubiquitin-dependent protein catabolic process|
|transport along microtubule|
|cytoskeleton-dependent intracellular transport|
|microtubule-based transport|
|regulation of proteasomal protein catabolic process|
|regulation of microtubule cytoskeleton organization|
|regulation of synaptic plasticity|
|structural molecule activity|
|regulation of proteolysis involved in cellular protein catabolic process|
|regulation of microtubule-based process|
|microtubule binding|
|regulation of cellular protein catabolic process|
|negative regulation of cellular catabolic process|
|learning or memory|
|actin binding|
|synapse|
|microtubule-based movement|
|axon|
|cognition|
|negative regulation of catabolic process|
|microtubule|
|neuron projection|
|positive regulation of cellular protein localization|
|anatomical structure homeostasis|
|regulation of supramolecular fiber organization|
|negative regulation of proteolysis|
|neuronal cell body|
|axonogenesis|
|regulation of protein catabolic process|
|axon development|
|dendrite|
|cell morphogenesis involved in neuron differentiation|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|microtubule cytoskeleton organization|
|neuron projection morphogenesis|
|plasma membrane bounded cell projection morphogenesis|
|cell projection morphogenesis|
|cell part morphogenesis|
|regulation of cellular protein localization|
|regulation of cytoskeleton organization|
|cell morphogenesis involved in differentiation|
|behavior|
|neuron projection development|
|microtubule-based process|
|cell morphogenesis|
|regulation of proteolysis|
|neuron development|
|cellular component morphogenesis|
|regulation of cellular catabolic process|
|cellular homeostasis|
|regulation of cellular localization|
|intracellular protein transport|
|regulation of catabolic process|
|neuron differentiation|
|regulation of protein localization|
|negative regulation of cellular protein metabolic process|
|negative regulation of protein metabolic process|
|cytoskeleton organization|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|regulation of organelle organization|
|nervous system process|
|protein transport|
|intracellular transport|
|generation of neurons|
|peptide transport|
|movement of cell or subcellular component|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|neurogenesis|
|homeostatic process|
|cell development|
|establishment of localization in cell|
|nitrogen compound transport|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|-2.22|
|[[:results:exp537|WNT3A 44ng/ml R08 exp537]]|-1.92|
|[[:results:exp199|Etoposide 0.3μM R05 exp199]]|-1.77|
|[[:results:exp107|UMK57 0.6μM R03 exp107]]|-1.74|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4207
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.71 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MAP1A Expression in NALM6 Cells: 5.71'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>