MAP1A
Gene Information
- Official Symbol: MAP1A
- Official Name: microtubule associated protein 1A
- Aliases and Previous Symbols: N/A
- Entrez ID: 4130
- UniProt: P78559
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Structural protein involved in the filamentous cross- bridging between microtubules and other skeletal elements.
Pfam Domains GO Terms
Pfam Domains
No Pfam Domain information is available for this gene.
GO Terms
| primary dendrite |
| retrograde axonal protein transport |
| dendritic branch |
| dendritic microtubule |
| regulation of protein localization to microtubule |
| negative regulation of protein localization to microtubule |
| voluntary musculoskeletal movement |
| anterograde axonal protein transport |
| protein localization to presynapse |
| neuron projection maintenance |
| axo-dendritic protein transport |
| cytoskeletal adaptor activity |
| positive regulation of protein localization to cell surface |
| retrograde axonal transport |
| axon initial segment |
| regulation of microtubule depolymerization |
| microtubule associated complex |
| neuron cellular homeostasis |
| negative regulation of proteasomal ubiquitin-dependent protein catabolic process |
| dendritic shaft |
| regulation of protein localization to cell surface |
| neuron projection organization |
| musculoskeletal movement |
| multicellular organismal movement |
| anterograde axonal transport |
| tau protein binding |
| negative regulation of ubiquitin-dependent protein catabolic process |
| tubulin binding |
| axonal transport |
| negative regulation of proteasomal protein catabolic process |
| axon cytoplasm |
| protein localization to synapse |
| axo-dendritic transport |
| protein transport along microtubule |
| microtubule-based protein transport |
| negative regulation of proteolysis involved in cellular protein catabolic process |
| associative learning |
| regulation of microtubule polymerization or depolymerization |
| regulation of protein depolymerization |
| negative regulation of cellular protein catabolic process |
| cell projection |
| dendrite development |
| negative regulation of cellular protein localization |
| regulation of protein complex disassembly |
| memory |
| regulation of proteasomal ubiquitin-dependent protein catabolic process |
| negative regulation of protein catabolic process |
| learning |
| regulation of ubiquitin-dependent protein catabolic process |
| transport along microtubule |
| cytoskeleton-dependent intracellular transport |
| microtubule-based transport |
| regulation of proteasomal protein catabolic process |
| regulation of microtubule cytoskeleton organization |
| regulation of synaptic plasticity |
| structural molecule activity |
| regulation of proteolysis involved in cellular protein catabolic process |
| regulation of microtubule-based process |
| microtubule binding |
| regulation of cellular protein catabolic process |
| negative regulation of cellular catabolic process |
| learning or memory |
| actin binding |
| synapse |
| microtubule-based movement |
| axon |
| cognition |
| negative regulation of catabolic process |
| microtubule |
| neuron projection |
| positive regulation of cellular protein localization |
| anatomical structure homeostasis |
| regulation of supramolecular fiber organization |
| negative regulation of proteolysis |
| neuronal cell body |
| axonogenesis |
| regulation of protein catabolic process |
| axon development |
| dendrite |
| cell morphogenesis involved in neuron differentiation |
| modulation of chemical synaptic transmission |
| regulation of trans-synaptic signaling |
| microtubule cytoskeleton organization |
| neuron projection morphogenesis |
| plasma membrane bounded cell projection morphogenesis |
| cell projection morphogenesis |
| cell part morphogenesis |
| regulation of cellular protein localization |
| regulation of cytoskeleton organization |
| cell morphogenesis involved in differentiation |
| behavior |
| neuron projection development |
| microtubule-based process |
| cell morphogenesis |
| regulation of proteolysis |
| neuron development |
| cellular component morphogenesis |
| regulation of cellular catabolic process |
| cellular homeostasis |
| regulation of cellular localization |
| intracellular protein transport |
| regulation of catabolic process |
| neuron differentiation |
| regulation of protein localization |
| negative regulation of cellular protein metabolic process |
| negative regulation of protein metabolic process |
| cytoskeleton organization |
| plasma membrane bounded cell projection organization |
| cell projection organization |
| regulation of organelle organization |
| nervous system process |
| protein transport |
| intracellular transport |
| generation of neurons |
| peptide transport |
| movement of cell or subcellular component |
| amide transport |
| cellular protein localization |
| cellular macromolecule localization |
| establishment of protein localization |
| neurogenesis |
| homeostatic process |
| cell development |
| establishment of localization in cell |
| nitrogen compound transport |
| system process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Mdivi-1 15μM R05 exp217 | -2.22 |
| WNT3A 44ng/ml R08 exp537 | -1.92 |
| Etoposide 0.3μM R05 exp199 | -1.77 |
| UMK57 0.6μM R03 exp107 | -1.74 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 4207
- Expression level (log2 read counts): 5.71
Expression Distribution
MAP1A Expression in NALM6 Cells: 5.71
