MAP2 [The Human Chemical-Genetic Interaction Map Project]

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======= MAP2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MAP2
  * **<color #00a2e8>Official Name</color>**: microtubule associated protein 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4133|4133]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P11137|P11137]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MAP2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MAP2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/157130|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a protein that belongs to the microtubule-associated protein family. The proteins of this family are thought to be involved in microtubule assembly, which is an essential step in neurogenesis. The products of similar genes in rat and mouse are neuron-specific cytoskeletal proteins that are enriched in dentrites, implicating a role in determining and stabilizing dentritic shape during neuron development. A number of alternatively spliced variants encoding distinct isoforms have been described. [provided by RefSeq, Jan 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**:  The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|MAP2 projctn|
|Tubulin-binding|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of microtubule motor activity|
|distal dendrite|
|apical distal dendrite|
|positive regulation of dense core granule transport|
|negative regulation of microtubule binding|
|regulation of anterograde dense core granule transport|
|primary dendrite|
|positive regulation of anterograde dense core granule transport|
|dendritic filopodium|
|regulation of dense core granule transport|
|positive regulation of synaptic vesicle transport|
|positive regulation of anterograde synaptic vesicle transport|
|positive regulation of vesicle transport along microtubule|
|regulation of anterograde synaptic vesicle transport|
|dendritic branch|
|CA3 pyramidal cell dendrite|
|proximal neuron projection|
|regulation of vesicle transport along microtubule|
|proximal dendrite|
|basal dendrite|
|main axon|
|regulation of synaptic vesicle transport|
|axon hillock|
|dendritic growth cone|
|dystroglycan binding|
|regulation of organelle transport along microtubule|
|regulation of microtubule motor activity|
|regulation of microtubule binding|
|positive regulation of cytoplasmic transport|
|negative regulation of microtubule polymerization|
|nuclear periphery|
|axon initial segment|
|regulation of cytoplasmic transport|
|regulation of microtubule-based movement|
|dendrite cytoplasm|
|microtubule associated complex|
|dendritic shaft|
|negative regulation of microtubule polymerization or depolymerization|
|negative regulation of axon extension|
|tau protein binding|
|regulation of microtubule polymerization|
|dendrite morphogenesis|
|negative regulation of protein polymerization|
|negative regulation of axonogenesis|
|regulation of microtubule polymerization or depolymerization|
|central nervous system neuron development|
|microtubule bundle formation|
|regulation of axon extension|
|negative regulation of cell morphogenesis involved in differentiation|
|negative regulation of protein binding|
|dendrite development|
|negative regulation of developmental growth|
|regulation of extent of cell growth|
|establishment of cell polarity|
|negative regulation of supramolecular fiber organization|
|negative regulation of protein complex assembly|
|negative regulation of cytoskeleton organization|
|negative regulation of neuron projection development|
|negative regulation of binding|
|central nervous system neuron differentiation|
|negative regulation of cell projection organization|
|regulation of cell size|
|negative regulation of cell growth|
|regulation of axonogenesis|
|regulation of microtubule cytoskeleton organization|
|structural molecule activity|
|establishment or maintenance of cell polarity|
|calmodulin binding|
|positive regulation of intracellular transport|
|regulation of protein binding|
|regulation of microtubule-based process|
|regulation of protein polymerization|
|negative regulation of neuron differentiation|
|microtubule binding|
|negative regulation of growth|
|postsynaptic density|
|negative regulation of neurogenesis|
|regulation of cell morphogenesis involved in differentiation|
|negative regulation of nervous system development|
|microtubule|
|neuron projection|
|regulation of developmental growth|
|negative regulation of cell development|
|regulation of intracellular transport|
|regulation of supramolecular fiber organization|
|neuronal cell body|
|axonogenesis|
|negative regulation of organelle organization|
|regulation of cellular component size|
|regulation of binding|
|axon development|
|regulation of cell growth|
|dendrite|
|cell morphogenesis involved in neuron differentiation|
|regulation of protein complex assembly|
|negative regulation of hydrolase activity|
|microtubule cytoskeleton organization|
|neuron projection morphogenesis|
|plasma membrane bounded cell projection morphogenesis|
|regulation of cell morphogenesis|
|cell projection morphogenesis|
|regulation of neuron projection development|
|cell part morphogenesis|
|regulation of anatomical structure size|
|positive regulation of cellular component movement|
|regulation of cellular protein localization|
|regulation of cytoskeleton organization|
|cell morphogenesis involved in differentiation|
|regulation of neuron differentiation|
|neuron projection development|
|regulation of growth|
|microtubule-based process|
|regulation of plasma membrane bounded cell projection organization|
|negative regulation of cellular component organization|
|regulation of cell projection organization|
|negative regulation of cell differentiation|
|cell morphogenesis|
|negative regulation of catalytic activity|
|neuron development|
|regulation of neurogenesis|
|cellular component morphogenesis|
|nucleolus|
|regulation of cellular localization|
|regulation of nervous system development|
|regulation of cell development|
|negative regulation of developmental process|
|regulation of cellular component biogenesis|
|central nervous system development|
|positive regulation of transport|
|regulation of cellular component movement|
|neuron differentiation|
|regulation of protein localization|
|regulation of anatomical structure morphogenesis|
|cytoskeleton organization|
|plasma membrane bounded cell projection organization|
|negative regulation of molecular function|
|cell projection organization|
|negative regulation of multicellular organismal process|
|regulation of hydrolase activity|
|regulation of organelle organization|
|generation of neurons|
|neurogenesis|
|cell development|
|regulation of cell differentiation|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp336|Asunaprenir 3μM R07 exp336]]|-1.77|
|[[:results:exp219|A-395N 10μM R05 exp219]]|1.73|
|[[:results:exp97|BI-6727 0.0125μM R03 exp97]]|1.96|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14529
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.25 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MAP2 Expression in NALM6 Cells: 4.25'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>