MAP2

Entrez Summary: This gene encodes a protein that belongs to the microtubule-associated protein family. The proteins of this family are thought to be involved in microtubule assembly, which is an essential step in neurogenesis. The products of similar genes in rat and mouse are neuron-specific cytoskeletal proteins that are enriched in dentrites, implicating a role in determining and stabilizing dentritic shape during neuron development. A number of alternatively spliced variants encoding distinct isoforms have been described. [provided by RefSeq, Jan 2010].
UniProt Summary: The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

MAP2 projctn
Tubulin-binding

negative regulation of microtubule motor activity
distal dendrite
apical distal dendrite
positive regulation of dense core granule transport
negative regulation of microtubule binding
regulation of anterograde dense core granule transport
primary dendrite
positive regulation of anterograde dense core granule transport
dendritic filopodium
regulation of dense core granule transport
positive regulation of synaptic vesicle transport
positive regulation of anterograde synaptic vesicle transport
positive regulation of vesicle transport along microtubule
regulation of anterograde synaptic vesicle transport
dendritic branch
CA3 pyramidal cell dendrite
proximal neuron projection
regulation of vesicle transport along microtubule
proximal dendrite
basal dendrite
main axon
regulation of synaptic vesicle transport
axon hillock
dendritic growth cone
dystroglycan binding
regulation of organelle transport along microtubule
regulation of microtubule motor activity
regulation of microtubule binding
positive regulation of cytoplasmic transport
negative regulation of microtubule polymerization
nuclear periphery
axon initial segment
regulation of cytoplasmic transport
regulation of microtubule-based movement
dendrite cytoplasm
microtubule associated complex
dendritic shaft
negative regulation of microtubule polymerization or depolymerization
negative regulation of axon extension
tau protein binding