MAP2K7

Gene Information

Official Symbol: MAP2K7
Official Name: mitogen-activated protein kinase kinase 7
Aliases and Previous Symbols: N/A
Entrez ID: 5609
UniProt: O14733
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically activates MAPK8/JNK1 and MAPK9/JNK2, and this kinase itself is phosphorylated and activated by MAP kinase kinase kinases including MAP3K1/MEKK1, MAP3K2/MEKK2,MAP3K3/MEKK5, and MAP4K2/GCK. This kinase is involved in the signal transduction mediating the cell responses to proinflammatory cytokines, and environmental stresses. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014].
UniProt Summary: N/A

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	1/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 11140
Expression level (log2 read counts): 5.89

Expression Distribution

Screen	Score
Etoposide 1μM R00 exp19	-1.92
A-366 10μM R03 exp115	1.72

Pkinase Tyr
Pkinase

JUN kinase kinase activity
MAP kinase kinase activity
positive regulation of telomere capping
regulation of telomere capping
positive regulation of telomere maintenance via telomerase
positive regulation of telomerase activity
positive regulation of telomere maintenance via telomere lengthening
activation of JUN kinase activity
positive regulation of telomere maintenance
regulation of telomerase activity
regulation of telomere maintenance via telomerase
regulation of telomere maintenance via telomere lengthening
positive regulation of DNA biosynthetic process
positive regulation of JUN kinase activity
response to osmotic stress
JNK cascade
regulation of telomere maintenance
protein phosphatase binding
regulation of JUN kinase activity
protein tyrosine kinase activity
stress-activated MAPK cascade
response to heat
regulation of DNA biosynthetic process
positive regulation of JNK cascade
stress-activated protein kinase signaling cascade
response to UV
peptidyl-tyrosine phosphorylation
peptidyl-tyrosine modification
activation of MAPK activity
positive regulation of stress-activated MAPK cascade
positive regulation of stress-activated protein kinase signaling cascade
Fc-epsilon receptor signaling pathway
positive regulation of chromosome organization
response to temperature stimulus
regulation of JNK cascade
positive regulation of DNA metabolic process
positive regulation of ERK1 and ERK2 cascade
magnesium ion binding
regulation of stress-activated MAPK cascade
regulation of stress-activated protein kinase signaling cascade