MAP3K13 [The Human Chemical-Genetic Interaction Map Project]

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======= MAP3K13 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MAP3K13
  * **<color #00a2e8>Official Name</color>**: mitogen-activated protein kinase kinase kinase 13
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9175|9175]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O43283|O43283]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MAP3K13&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MAP3K13|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604915|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7. Acts synergistically with PRDX3 to regulate the activation of NF-kappa-B in the cytosol. This activation is kinase-dependent and involves activating the IKK complex, the IKBKB-containing complex that phosphorylates inhibitors of NF-kappa-B. {ECO:0000269|PubMed:11726277, ECO:0000269|PubMed:12492477, ECO:0000269|PubMed:9353328}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Pkinase|
|Pkinase Tyr|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|IkappaB kinase complex binding|
|positive regulation of branching morphogenesis of a nerve|
|positive regulation of neuron maturation|
|regulation of branching morphogenesis of a nerve|
|positive regulation of neuron projection arborization|
|JUN kinase kinase kinase activity|
|positive regulation of cell maturation|
|regulation of neuron projection arborization|
|regulation of neuron maturation|
|activation of JNKK activity|
|MAP kinase kinase kinase activity|
|regulation of cell maturation|
|activation of JUN kinase activity|
|positive regulation of axon extension|
|activation of MAPKK activity|
|regulation of morphogenesis of a branching structure|
|positive regulation of JUN kinase activity|
|JNK cascade|
|positive regulation of axonogenesis|
|regulation of JUN kinase activity|
|regulation of axon extension|
|stress-activated MAPK cascade|
|regulation of extent of cell growth|
|positive regulation of JNK cascade|
|stress-activated protein kinase signaling cascade|
|positive regulation of NF-kappaB transcription factor activity|
|positive regulation of cell morphogenesis involved in differentiation|
|activation of MAPK activity|
|positive regulation of cell growth|
|positive regulation of stress-activated MAPK cascade|
|positive regulation of stress-activated protein kinase signaling cascade|
|positive regulation of developmental growth|
|peptidyl-serine phosphorylation|
|regulation of cell size|
|regulation of axonogenesis|
|regulation of JNK cascade|
|protein autophosphorylation|
|peptidyl-serine modification|
|regulation of stress-activated MAPK cascade|
|regulation of stress-activated protein kinase signaling cascade|
|positive regulation of growth|
|positive regulation of DNA-binding transcription factor activity|
|positive regulation of MAP kinase activity|
|positive regulation of neuron projection development|
|regulation of cell morphogenesis involved in differentiation|
|activation of protein kinase activity|
|regulation of developmental growth|
|positive regulation of protein serine/threonine kinase activity|
|regulation of MAP kinase activity|
|enzyme binding|
|protein serine/threonine kinase activity|
|positive regulation of neuron differentiation|
|MAPK cascade|
|regulation of cellular component size|
|positive regulation of cell projection organization|
|signal transduction by protein phosphorylation|
|regulation of cell growth|
|regulation of DNA-binding transcription factor activity|
|protein kinase binding|
|positive regulation of neurogenesis|
|regulation of cell morphogenesis|
|regulation of neuron projection development|
|regulation of anatomical structure size|
|regulation of protein serine/threonine kinase activity|
|positive regulation of protein kinase activity|
|positive regulation of nervous system development|
|positive regulation of cell development|
|positive regulation of MAPK cascade|
|positive regulation of kinase activity|
|regulation of neuron differentiation|
|positive regulation of transferase activity|
|regulation of growth|
|regulation of plasma membrane bounded cell projection organization|
|regulation of cell projection organization|
|regulation of cellular response to stress|
|regulation of MAPK cascade|
|regulation of protein kinase activity|
|regulation of neurogenesis|
|regulation of kinase activity|
|protein homodimerization activity|
|peptidyl-amino acid modification|
|regulation of nervous system development|
|regulation of cell development|
|positive regulation of cell differentiation|
|protein phosphorylation|
|regulation of transferase activity|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|positive regulation of phosphorylation|
|regulation of anatomical structure morphogenesis|
|identical protein binding|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|positive regulation of cellular component organization|
|positive regulation of protein modification process|
|phosphorylation|
|positive regulation of developmental process|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|regulation of response to stress|
|ATP binding|
|generation of neurons|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|neurogenesis|
|positive regulation of signal transduction|
|intracellular signal transduction|
|cellular response to stress|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp132|Metformin 40μM R03 exp132]]|-1.88|
|[[:results:exp279|D-Fructose 10000μM R06 exp279]]|-1.87|
|[[:results:exp298|Sucrose 20000μM R06 exp298]]|-1.83|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|1.84|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11409
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.58 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MAP3K13 Expression in NALM6 Cells: 4.58'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>