MAP3K13
Gene Information
- Official Symbol: MAP3K13
- Official Name: mitogen-activated protein kinase kinase kinase 13
- Aliases and Previous Symbols: N/A
- Entrez ID: 9175
- UniProt: O43283
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7. Acts synergistically with PRDX3 to regulate the activation of NF-kappa-B in the cytosol. This activation is kinase-dependent and involves activating the IKK complex, the IKBKB-containing complex that phosphorylates inhibitors of NF-kappa-B. {ECO:0000269|PubMed:11726277, ECO:0000269|PubMed:12492477, ECO:0000269|PubMed:9353328}.
Pfam Domains GO Terms
Pfam Domains
| Pkinase |
| Pkinase Tyr |
GO Terms
| IkappaB kinase complex binding |
| positive regulation of branching morphogenesis of a nerve |
| positive regulation of neuron maturation |
| regulation of branching morphogenesis of a nerve |
| positive regulation of neuron projection arborization |
| JUN kinase kinase kinase activity |
| positive regulation of cell maturation |
| regulation of neuron projection arborization |
| regulation of neuron maturation |
| activation of JNKK activity |
| MAP kinase kinase kinase activity |
| regulation of cell maturation |
| activation of JUN kinase activity |
| positive regulation of axon extension |
| activation of MAPKK activity |
| regulation of morphogenesis of a branching structure |
| positive regulation of JUN kinase activity |
| JNK cascade |
| positive regulation of axonogenesis |
| regulation of JUN kinase activity |
| regulation of axon extension |
| stress-activated MAPK cascade |
| regulation of extent of cell growth |
| positive regulation of JNK cascade |
| stress-activated protein kinase signaling cascade |
| positive regulation of NF-kappaB transcription factor activity |
| positive regulation of cell morphogenesis involved in differentiation |
| activation of MAPK activity |
| positive regulation of cell growth |
| positive regulation of stress-activated MAPK cascade |
| positive regulation of stress-activated protein kinase signaling cascade |
| positive regulation of developmental growth |
| peptidyl-serine phosphorylation |
| regulation of cell size |
| regulation of axonogenesis |
| regulation of JNK cascade |
| protein autophosphorylation |
| peptidyl-serine modification |
| regulation of stress-activated MAPK cascade |
| regulation of stress-activated protein kinase signaling cascade |
| positive regulation of growth |
| positive regulation of DNA-binding transcription factor activity |
| positive regulation of MAP kinase activity |
| positive regulation of neuron projection development |
| regulation of cell morphogenesis involved in differentiation |
| activation of protein kinase activity |
| regulation of developmental growth |
| positive regulation of protein serine/threonine kinase activity |
| regulation of MAP kinase activity |
| enzyme binding |
| protein serine/threonine kinase activity |
| positive regulation of neuron differentiation |
| MAPK cascade |
| regulation of cellular component size |
| positive regulation of cell projection organization |
| signal transduction by protein phosphorylation |
| regulation of cell growth |
| regulation of DNA-binding transcription factor activity |
| protein kinase binding |
| positive regulation of neurogenesis |
| regulation of cell morphogenesis |
| regulation of neuron projection development |
| regulation of anatomical structure size |
| regulation of protein serine/threonine kinase activity |
| positive regulation of protein kinase activity |
| positive regulation of nervous system development |
| positive regulation of cell development |
| positive regulation of MAPK cascade |
| positive regulation of kinase activity |
| regulation of neuron differentiation |
| positive regulation of transferase activity |
| regulation of growth |
| regulation of plasma membrane bounded cell projection organization |
| regulation of cell projection organization |
| regulation of cellular response to stress |
| regulation of MAPK cascade |
| regulation of protein kinase activity |
| regulation of neurogenesis |
| regulation of kinase activity |
| protein homodimerization activity |
| peptidyl-amino acid modification |
| regulation of nervous system development |
| regulation of cell development |
| positive regulation of cell differentiation |
| protein phosphorylation |
| regulation of transferase activity |
| positive regulation of protein phosphorylation |
| positive regulation of intracellular signal transduction |
| positive regulation of phosphorylation |
| regulation of anatomical structure morphogenesis |
| identical protein binding |
| positive regulation of phosphorus metabolic process |
| positive regulation of phosphate metabolic process |
| positive regulation of cellular component organization |
| positive regulation of protein modification process |
| phosphorylation |
| positive regulation of developmental process |
| positive regulation of catalytic activity |
| regulation of protein phosphorylation |
| regulation of response to stress |
| ATP binding |
| generation of neurons |
| regulation of phosphorylation |
| positive regulation of cellular protein metabolic process |
| neurogenesis |
| positive regulation of signal transduction |
| intracellular signal transduction |
| cellular response to stress |
| positive regulation of protein metabolic process |
| positive regulation of multicellular organismal process |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of cell differentiation |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| regulation of protein modification process |
| membrane |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Metformin 40μM R03 exp132 | -1.88 |
| D-Fructose 10000μM R06 exp279 | -1.87 |
| Sucrose 20000μM R06 exp298 | -1.83 |
| Etoposide 1μM R00 exp19 | 1.84 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 11409
- Expression level (log2 read counts): 4.58
Expression Distribution
MAP3K13 Expression in NALM6 Cells: 4.58
