MAP3K3

Gene Information

Official Symbol: MAP3K3
Official Name: mitogen-activated protein kinase kinase kinase 3
Aliases and Previous Symbols: N/A
Entrez ID: 4215
UniProt: Q99759
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Component of a protein kinase signal transduction cascade. Mediates activation of the NF-kappa-B, AP1 and DDIT3 transcriptional regulators. {ECO:0000269|PubMed:12912994, ECO:0000269|PubMed:14661019, ECO:0000269|PubMed:14743216, ECO:0000269|PubMed:9006902}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 6345
Expression level (log2 read counts): 5.42

Expression Distribution

PB1
Pkinase
Pkinase Tyr

positive regulation of cell proliferation in bone marrow
regulation of cell proliferation in bone marrow
negative regulation of cellular senescence
MAP kinase kinase kinase activity
positive regulation of cell migration involved in sprouting angiogenesis
negative regulation of cell aging
positive regulation of p38MAPK cascade
regulation of cell migration involved in sprouting angiogenesis
positive regulation of sprouting angiogenesis
regulation of p38MAPK cascade
regulation of cellular senescence
regulation of cell aging
activation of MAPKK activity
positive regulation of blood vessel endothelial cell migration
regulation of sprouting angiogenesis
regulation of blood vessel endothelial cell migration
interleukin-1-mediated signaling pathway
positive regulation of endothelial cell migration
positive regulation of epithelial cell migration
stress-activated protein kinase signaling cascade
regulation of endothelial cell migration
positive regulation of angiogenesis
positive regulation of stress-activated MAPK cascade
positive regulation of stress-activated protein kinase signaling cascade
cellular response to interleukin-1
positive regulation of vasculature development
positive regulation of I-kappaB kinase/NF-kappaB signaling
protein autophosphorylation
response to interleukin-1
regulation of epithelial cell migration
regulation of stress-activated MAPK cascade
regulation of I-kappaB kinase/NF-kappaB signaling
regulation of stress-activated protein kinase signaling cascade
protein kinase activity
positive regulation of MAP kinase activity
regulation of angiogenesis
regulation of vasculature development
activation of protein kinase activity
positive regulation of protein serine/threonine kinase activity
regulation of MAP kinase activity