MAPKAP1 [The Human Chemical-Genetic Interaction Map Project]

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======= MAPKAP1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MAPKAP1
  * **<color #00a2e8>Official Name</color>**: MAPK associated protein 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=79109|79109]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9BPZ7|Q9BPZ7]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MAPKAP1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MAPKAP1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610558|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SIN1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|TORC2 signaling|
|TORC2 complex|
|establishment or maintenance of actin cytoskeleton polarity|
|Ras GTPase binding|
|establishment or maintenance of cytoskeleton polarity|
|phosphatidic acid binding|
|phosphatidylinositol-3,5-bisphosphate binding|
|TOR signaling|
|phosphatidylinositol-3,4-bisphosphate binding|
|activation of protein kinase B activity|
|phosphatidylinositol-3,4,5-trisphosphate binding|
|substantia nigra development|
|negative regulation of Ras protein signal transduction|
|negative regulation of small GTPase mediated signal transduction|
|neural nucleus development|
|regulation of cellular response to oxidative stress|
|phosphatidylinositol-4,5-bisphosphate binding|
|regulation of response to oxidative stress|
|midbrain development|
|positive regulation of peptidyl-serine phosphorylation|
|regulation of peptidyl-serine phosphorylation|
|establishment or maintenance of cell polarity|
|regulation of Ras protein signal transduction|
|cytoplasmic vesicle|
|activation of protein kinase activity|
|regulation of small GTPase mediated signal transduction|
|protein kinase binding|
|actin cytoskeleton organization|
|negative regulation of intracellular signal transduction|
|positive regulation of protein kinase activity|
|actin filament-based process|
|positive regulation of kinase activity|
|positive regulation of transferase activity|
|regulation of cellular response to stress|
|brain development|
|head development|
|regulation of protein kinase activity|
|regulation of kinase activity|
|regulation of transferase activity|
|central nervous system development|
|Golgi apparatus|
|positive regulation of protein phosphorylation|
|positive regulation of phosphorylation|
|cytoskeleton organization|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|positive regulation of protein modification process|
|negative regulation of signal transduction|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|regulation of response to stress|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|negative regulation of response to stimulus|
|intracellular signal transduction|
|positive regulation of protein metabolic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|-2.97|
|[[:results:exp38|Wortmannin 5μM R00 exp38]]|-2.58|
|[[:results:exp426|FBS-Wisent 0.1 R07 exp426]]|-2.52|
|[[:results:exp346|CoCl2 18μM R07 exp346]]|-2.3|
|[[:results:exp223|Cabazitaxel 0.001μM R05 exp223]]|-2.29|
|[[:results:exp37|Wortmannin 0.5μM R00 exp37]]|-2.22|
|[[:results:exp32|Rifampicin 10μM R00 exp32]]|-2.19|
|[[:results:exp391|Pomalidomide 20μM R07 exp391]]|-2.05|
|[[:results:exp169|BH1 1μM R04 exp169]]|-2|
|[[:results:exp243|S-trityl-L-cysteine 0.5μM R05 exp243]]|-1.98|
|[[:results:exp176|Apcin 50 to 100μM on day4 R04 exp176]]|-1.97|
|[[:results:exp351|Dexamethasone 0.006μM R07 exp351]]|-1.94|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|-1.82|
|[[:results:exp534|Trientine 500μM R08 exp534]]|1.76|
|[[:results:exp532|TIC10 10μM R08 exp532]]|1.78|
|[[:results:exp487|Hinokiflavone 12μM R08 exp487]]|1.79|
|[[:results:exp85|UM0129480 7μM R02 exp85]]|1.79|
|[[:results:exp98|BI-6727 0.04μM R03 exp98]]|1.8|
|[[:results:exp233|EPZ-5676 30μM R05 exp233]]|1.8|
|[[:results:exp455|Benzoate 10000μM R08 exp455]]|1.81|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|1.83|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|1.85|
|[[:results:exp349|Cytochalasin-B 5μM R07 exp349]]|1.91|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|1.93|
|[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|1.93|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|1.94|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|1.95|
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|1.97|
|[[:results:exp431|Rotenone 0.07μM R08 exp431]]|1.97|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|1.98|
|[[:results:exp414|Tozasertib 0.1μM R07 exp414]]|2|
|[[:results:exp275|Citral 75μM R06 exp275]]|2.04|
|[[:results:exp447|Amiloride 100μM R08 exp447]]|2.06|
|[[:results:exp93|DABN racemic mixture R03 exp93]]|2.1|
|[[:results:exp259|6-Thio-2-deoxyguanosine 2μM R06 exp259]]|2.17|
|[[:results:exp472|CI-1040 9.5μM R08 exp472]]|2.21|
|[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|2.21|
|[[:results:exp531|THZ1 0.06μM R08 exp531]]|2.22|
|[[:results:exp446|4-Nitroquinoline-1-oxide 0.5μM R08 exp446]]|2.25|
|[[:results:exp294|Nutlin-3A 1.6μM R06 exp294]]|2.29|
|[[:results:exp513|ONC212 0.15μM R08 exp513]]|2.31|
|[[:results:exp334|All-trans-Retinoic-Acid 40μM R07 exp334]]|2.32|
|[[:results:exp269|Bisphenol A 100μM R06 exp269]]|2.36|
|[[:results:exp518|RK-33 8μM R08 exp518]]|2.39|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|2.41|
|[[:results:exp274|Citral 50μM R06 exp274]]|2.44|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|2.44|
|[[:results:exp111|R-DABN 8μM R03 exp111]]|2.48|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|2.5|
|[[:results:exp120|Dimethyl-Sulfoxide 1pc R03 exp120]]|2.59|
|[[:results:exp354|Diepoxybutane 3μM R07 exp354]]|2.83|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|2.87|
|[[:results:exp520|Rucaparib 6.5μM R08 exp520]]|2.98|
|[[:results:exp256|HMS-I1 10μM R06 exp256]]|3.06|
|[[:results:exp211|AICAR 240μM R05 exp211]]|3.38|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|3.44|
|[[:results:exp497|Lead acetate 2000μM R08 exp497]]|3.5|
|[[:results:exp102|Nifuroxazide 5μM R03 exp102]]|3.51|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|3.58|
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|3.86|
|[[:results:exp135|MS023 7μM R03 exp135]]|4.01|
|[[:results:exp456|Benzoate 20000μM R08 exp456]]|4.04|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|4.14|
|[[:results:exp526|Sulforaphane 9μM R08 exp526 no dilution day6]]|4.15|
|[[:results:exp498|Lead acetate 2000μM R08 exp498 no dilution day6]]|4.35|
|[[:results:exp134|MS023 2μM R03 exp134]]|4.4|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|4.53|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|4.59|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|4.63|
|[[:results:exp525|Sulforaphane 9μM R08 exp525]]|4.73|
|[[:results:exp116|AICAR 240μM R03 exp116]]|4.89|
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|6.36|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rictor|RICTOR]]|0.821|
|[[:human genes:p:pdpk1|PDPK1]]|0.754|
|[[:human genes:m:mlst8|MLST8]]|0.753|
|[[:human genes:a:akt2|AKT2]]|0.749|
|[[:human genes:c:cd81|CD81]]|0.748|
|[[:human genes:p:pik3cd|PIK3CD]]|0.747|
|[[:human genes:s:syk|SYK]]|0.697|
|[[:human genes:c:cd19|CD19]]|0.666|
|[[:human genes:r:rhoh|RHOH]]|0.639|
|[[:human genes:a:akt1|AKT1]]|0.544|
|[[:human genes:i:igll1|IGLL1]]|0.54|
|[[:human genes:d:dohh|DOHH]]|0.514|
|[[:human genes:b:bak1|BAK1]]|0.489|
|[[:human genes:b:bcl2l11|BCL2L11]]|0.476|
|[[:human genes:d:dph5|DPH5]]|0.474|
|[[:human genes:v:vezf1|VEZF1]]|0.472|
|[[:human genes:g:gnas|GNAS]]|0.471|
|[[:human genes:m:mocs3|MOCS3]]|0.47|
|[[:human genes:p:prrc2c|PRRC2C]]|0.465|
|[[:human genes:d:dph6|DPH6]]|0.465|
|[[:human genes:n:nsd1|NSD1]]|0.459|
|[[:human genes:p:pik3r1|PIK3R1]]|0.456|
|[[:human genes:u:urm1|URM1]]|0.456|
|[[:human genes:t:thg1l|THG1L]]|0.451|
|[[:human genes:d:dph1|DPH1]]|0.449|
|[[:human genes:z:zzz3|ZZZ3]]|0.443|
|[[:human genes:v:vdac2|VDAC2]]|0.442|
|[[:human genes:r:romo1|ROMO1]]|0.432|
|[[:human genes:h:h2afz|H2AFZ]]|0.432|
|[[:human genes:i:ints10|INTS10]]|0.428|
|[[:human genes:k:kdm3b|KDM3B]]|0.419|
|[[:human genes:t:trmt61a|TRMT61A]]|0.418|
|[[:human genes:e:elp3|ELP3]]|0.416|
|[[:human genes:c:cd79a|CD79A]]|0.416|
|[[:human genes:e:ergic1|ERGIC1]]|0.413|
|[[:human genes:m:midn|MIDN]]|0.411|
|[[:human genes:z:znhit1|ZNHIT1]]|0.411|
|[[:human genes:t:taf4|TAF4]]|0.408|
|[[:human genes:k:kdsr|KDSR]]|0.408|
|[[:human genes:n:n6amt1|N6AMT1]]|0.406|
|[[:human genes:p:pqbp1|PQBP1]]|0.406|
|[[:human genes:b:bap1|BAP1]]|0.405|
|[[:human genes:c:casp9|CASP9]]|0.405|
|[[:human genes:b:bptf|BPTF]]|0.402|
|[[:human genes:m:mtor|MTOR]]|0.4|
|[[:human genes:t:tgif1|TGIF1]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 2/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|1/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3895
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.48 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MAPKAP1 Expression in NALM6 Cells: 6.48'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>