MAPKAP1
Gene Information
- Official Symbol: MAPKAP1
- Official Name: MAPK associated protein 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 79109
- UniProt: Q9BPZ7
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| SIN1 |
GO Terms
| TORC2 signaling |
| TORC2 complex |
| establishment or maintenance of actin cytoskeleton polarity |
| Ras GTPase binding |
| establishment or maintenance of cytoskeleton polarity |
| phosphatidic acid binding |
| phosphatidylinositol-3,5-bisphosphate binding |
| TOR signaling |
| phosphatidylinositol-3,4-bisphosphate binding |
| activation of protein kinase B activity |
| phosphatidylinositol-3,4,5-trisphosphate binding |
| substantia nigra development |
| negative regulation of Ras protein signal transduction |
| negative regulation of small GTPase mediated signal transduction |
| neural nucleus development |
| regulation of cellular response to oxidative stress |
| phosphatidylinositol-4,5-bisphosphate binding |
| regulation of response to oxidative stress |
| midbrain development |
| positive regulation of peptidyl-serine phosphorylation |
| regulation of peptidyl-serine phosphorylation |
| establishment or maintenance of cell polarity |
| regulation of Ras protein signal transduction |
| cytoplasmic vesicle |
| activation of protein kinase activity |
| regulation of small GTPase mediated signal transduction |
| protein kinase binding |
| actin cytoskeleton organization |
| negative regulation of intracellular signal transduction |
| positive regulation of protein kinase activity |
| actin filament-based process |
| positive regulation of kinase activity |
| positive regulation of transferase activity |
| regulation of cellular response to stress |
| brain development |
| head development |
| regulation of protein kinase activity |
| regulation of kinase activity |
| regulation of transferase activity |
| central nervous system development |
| Golgi apparatus |
| positive regulation of protein phosphorylation |
| positive regulation of phosphorylation |
| cytoskeleton organization |
| positive regulation of phosphate metabolic process |
| positive regulation of phosphorus metabolic process |
| positive regulation of protein modification process |
| negative regulation of signal transduction |
| negative regulation of cell communication |
| negative regulation of signaling |
| positive regulation of catalytic activity |
| regulation of protein phosphorylation |
| regulation of response to stress |
| regulation of phosphorylation |
| positive regulation of cellular protein metabolic process |
| negative regulation of response to stimulus |
| intracellular signal transduction |
| positive regulation of protein metabolic process |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of intracellular signal transduction |
| regulation of protein modification process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| RICTOR | 0.821 |
| PDPK1 | 0.754 |
| MLST8 | 0.753 |
| AKT2 | 0.749 |
| CD81 | 0.748 |
| PIK3CD | 0.747 |
| SYK | 0.697 |
| CD19 | 0.666 |
| RHOH | 0.639 |
| AKT1 | 0.544 |
| IGLL1 | 0.54 |
| DOHH | 0.514 |
| BAK1 | 0.489 |
| BCL2L11 | 0.476 |
| DPH5 | 0.474 |
| VEZF1 | 0.472 |
| GNAS | 0.471 |
| MOCS3 | 0.47 |
| PRRC2C | 0.465 |
| DPH6 | 0.465 |
| NSD1 | 0.459 |
| PIK3R1 | 0.456 |
| URM1 | 0.456 |
| THG1L | 0.451 |
| DPH1 | 0.449 |
| ZZZ3 | 0.443 |
| VDAC2 | 0.442 |
| ROMO1 | 0.432 |
| H2AFZ | 0.432 |
| INTS10 | 0.428 |
| KDM3B | 0.419 |
| TRMT61A | 0.418 |
| ELP3 | 0.416 |
| CD79A | 0.416 |
| ERGIC1 | 0.413 |
| MIDN | 0.411 |
| ZNHIT1 | 0.411 |
| TAF4 | 0.408 |
| KDSR | 0.408 |
| N6AMT1 | 0.406 |
| PQBP1 | 0.406 |
| BAP1 | 0.405 |
| CASP9 | 0.405 |
| BPTF | 0.402 |
| MTOR | 0.4 |
| TGIF1 | 0.4 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 2/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 1/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 3895
- Expression level (log2 read counts): 6.48
Expression Distribution
MAPKAP1 Expression in NALM6 Cells: 6.48
