MAPRE2

Entrez Summary: The protein encoded by this gene shares significant homology to the adenomatous polyposis coli (APC) protein-binding EB1 gene family. This protein is a microtubule-associated protein that is necessary for spindle symmetry during mitosis. It is thought to play a role in the tumorigenesis of colorectal cancers and the proliferative control of normal cells. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2012].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

CH
EB1

positive regulation of ARF protein signal transduction
protein localization to microtubule end
protein localization to microtubule plus-end
protein localization to microtubule
positive regulation of keratinocyte migration
regulation of keratinocyte migration
microtubule plus-end binding
regulation of ARF protein signal transduction
microtubule plus-end
spindle midzone
positive regulation of adherens junction organization
protein localization to microtubule cytoskeleton
protein localization to cytoskeleton
cytoplasmic microtubule
positive regulation of Ras protein signal transduction
regulation of adherens junction organization
positive regulation of small GTPase mediated signal transduction
regulation of microtubule polymerization or depolymerization
spindle assembly
positive regulation of epithelial cell migration
microtubule cytoskeleton
spindle organization
microtubule organizing center
regulation of microtubule cytoskeleton organization
regulation of epithelial cell migration
regulation of microtubule-based process
microtubule binding
regulation of Ras protein signal transduction
microtubule
regulation of small GTPase mediated signal transduction
positive regulation of GTPase activity
focal adhesion
protein kinase binding
microtubule cytoskeleton organization
regulation of GTPase activity
cell division
positive regulation of cell migration
positive regulation of cell motility
positive regulation of cellular component movement
regulation of cytoskeleton organization