MARCH7 [The Human Chemical-Genetic Interaction Map Project]

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======= MARCH7 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MARCHF7
  * **<color #00a2e8>Official Name</color>**: membrane associated ring-CH-type finger 7
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=64844|64844]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9H992|Q9H992]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MARCH7&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MARCH7|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/613334|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  E3 ubiquitin-protein ligase which may specifically enhance the E2 activity of HIP2. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. {ECO:0000269|PubMed:16868077}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|RINGv|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of protein autoubiquitination|
|regulation of protein autoubiquitination|
|MDM2/MDM4 family protein binding|
|positive regulation of protein polyubiquitination|
|negative regulation of DNA damage response, signal transduction by p53 class mediator|
|regulation of tolerance induction|
|negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|
|regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|
|regulation of protein polyubiquitination|
|negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator|
|regulation of intrinsic apoptotic signaling pathway by p53 class mediator|
|negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage|
|negative regulation of signal transduction by p53 class mediator|
|ubiquitin conjugating enzyme binding|
|regulation of DNA damage response, signal transduction by p53 class mediator|
|regulation of intrinsic apoptotic signaling pathway in response to DNA damage|
|negative regulation of proteasomal protein catabolic process|
|transferase activity|
|negative regulation of T cell proliferation|
|protein autoubiquitination|
|negative regulation of proteolysis involved in cellular protein catabolic process|
|negative regulation of protein ubiquitination|
|negative regulation of mononuclear cell proliferation|
|negative regulation of lymphocyte proliferation|
|negative regulation of leukocyte proliferation|
|ubiquitin binding|
|negative regulation of response to DNA damage stimulus|
|negative regulation of protein modification by small protein conjugation or removal|
|negative regulation of cellular protein catabolic process|
|negative regulation of intrinsic apoptotic signaling pathway|
|negative regulation of T cell activation|
|positive regulation of protein ubiquitination|
|negative regulation of leukocyte cell-cell adhesion|
|negative regulation of protein catabolic process|
|positive regulation of protein modification by small protein conjugation or removal|
|negative regulation of lymphocyte activation|
|regulation of T cell proliferation|
|regulation of intrinsic apoptotic signaling pathway|
|negative regulation of cell-cell adhesion|
|negative regulation of leukocyte activation|
|protein stabilization|
|regulation of signal transduction by p53 class mediator|
|regulation of proteasomal protein catabolic process|
|negative regulation of cell activation|
|regulation of protein ubiquitination|
|regulation of lymphocyte proliferation|
|regulation of mononuclear cell proliferation|
|regulation of proteolysis involved in cellular protein catabolic process|
|regulation of response to DNA damage stimulus|
|regulation of leukocyte proliferation|
|negative regulation of apoptotic signaling pathway|
|regulation of protein modification by small protein conjugation or removal|
|regulation of cellular protein catabolic process|
|negative regulation of cellular catabolic process|
|negative regulation of cell adhesion|
|regulation of protein stability|
|regulation of leukocyte cell-cell adhesion|
|negative regulation of catabolic process|
|regulation of T cell activation|
|negative regulation of proteolysis|
|regulation of protein catabolic process|
|regulation of cell-cell adhesion|
|regulation of apoptotic signaling pathway|
|negative regulation of immune system process|
|negative regulation of intracellular signal transduction|
|regulation of lymphocyte activation|
|negative regulation of protein modification process|
|regulation of leukocyte activation|
|regulation of cell activation|
|negative regulation of cell population proliferation|
|regulation of cell adhesion|
|protein ubiquitination|
|regulation of proteolysis|
|regulation of cellular response to stress|
|protein modification by small protein conjugation|
|regulation of cellular catabolic process|
|zinc ion binding|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|positive regulation of cell population proliferation|
|protein modification by small protein conjugation or removal|
|regulation of catabolic process|
|negative regulation of cell death|
|negative regulation of cellular protein metabolic process|
|negative regulation of protein metabolic process|
|positive regulation of protein modification process|
|negative regulation of signal transduction|
|negative regulation of cell communication|
|negative regulation of signaling|
|regulation of response to stress|
|regulation of apoptotic process|
|regulation of programmed cell death|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|regulation of immune system process|
|regulation of cell death|
|positive regulation of protein metabolic process|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp18|Doxycycline 10μM R00 exp18]]|-1.9|
|[[:results:exp15|Cycloheximide 0.2μM R00 exp15]]|1.91|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.517|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13473
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.98 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MARCH7 Expression in NALM6 Cells: 6.98'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>