MARCH7
Gene Information
- Official Symbol: MARCHF7
- Official Name: membrane associated ring-CH-type finger 7
- Aliases and Previous Symbols: N/A
- Entrez ID: 64844
- UniProt: Q9H992
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: E3 ubiquitin-protein ligase which may specifically enhance the E2 activity of HIP2. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. {ECO:0000269|PubMed:16868077}.
Pfam Domains GO Terms
Pfam Domains
| RINGv |
GO Terms
| negative regulation of protein autoubiquitination |
| regulation of protein autoubiquitination |
| MDM2/MDM4 family protein binding |
| positive regulation of protein polyubiquitination |
| negative regulation of DNA damage response, signal transduction by p53 class mediator |
| regulation of tolerance induction |
| negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator |
| regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator |
| regulation of protein polyubiquitination |
| negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator |
| regulation of intrinsic apoptotic signaling pathway by p53 class mediator |
| negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage |
| negative regulation of signal transduction by p53 class mediator |
| ubiquitin conjugating enzyme binding |
| regulation of DNA damage response, signal transduction by p53 class mediator |
| regulation of intrinsic apoptotic signaling pathway in response to DNA damage |
| negative regulation of proteasomal protein catabolic process |
| transferase activity |
| negative regulation of T cell proliferation |
| protein autoubiquitination |
| negative regulation of proteolysis involved in cellular protein catabolic process |
| negative regulation of protein ubiquitination |
| negative regulation of mononuclear cell proliferation |
| negative regulation of lymphocyte proliferation |
| negative regulation of leukocyte proliferation |
| ubiquitin binding |
| negative regulation of response to DNA damage stimulus |
| negative regulation of protein modification by small protein conjugation or removal |
| negative regulation of cellular protein catabolic process |
| negative regulation of intrinsic apoptotic signaling pathway |
| negative regulation of T cell activation |
| positive regulation of protein ubiquitination |
| negative regulation of leukocyte cell-cell adhesion |
| negative regulation of protein catabolic process |
| positive regulation of protein modification by small protein conjugation or removal |
| negative regulation of lymphocyte activation |
| regulation of T cell proliferation |
| regulation of intrinsic apoptotic signaling pathway |
| negative regulation of cell-cell adhesion |
| negative regulation of leukocyte activation |
| protein stabilization |
| regulation of signal transduction by p53 class mediator |
| regulation of proteasomal protein catabolic process |
| negative regulation of cell activation |
| regulation of protein ubiquitination |
| regulation of lymphocyte proliferation |
| regulation of mononuclear cell proliferation |
| regulation of proteolysis involved in cellular protein catabolic process |
| regulation of response to DNA damage stimulus |
| regulation of leukocyte proliferation |
| negative regulation of apoptotic signaling pathway |
| regulation of protein modification by small protein conjugation or removal |
| regulation of cellular protein catabolic process |
| negative regulation of cellular catabolic process |
| negative regulation of cell adhesion |
| regulation of protein stability |
| regulation of leukocyte cell-cell adhesion |
| negative regulation of catabolic process |
| regulation of T cell activation |
| negative regulation of proteolysis |
| regulation of protein catabolic process |
| regulation of cell-cell adhesion |
| regulation of apoptotic signaling pathway |
| negative regulation of immune system process |
| negative regulation of intracellular signal transduction |
| regulation of lymphocyte activation |
| negative regulation of protein modification process |
| regulation of leukocyte activation |
| regulation of cell activation |
| negative regulation of cell population proliferation |
| regulation of cell adhesion |
| protein ubiquitination |
| regulation of proteolysis |
| regulation of cellular response to stress |
| protein modification by small protein conjugation |
| regulation of cellular catabolic process |
| zinc ion binding |
| negative regulation of apoptotic process |
| negative regulation of programmed cell death |
| positive regulation of cell population proliferation |
| protein modification by small protein conjugation or removal |
| regulation of catabolic process |
| negative regulation of cell death |
| negative regulation of cellular protein metabolic process |
| negative regulation of protein metabolic process |
| positive regulation of protein modification process |
| negative regulation of signal transduction |
| negative regulation of cell communication |
| negative regulation of signaling |
| regulation of response to stress |
| regulation of apoptotic process |
| regulation of programmed cell death |
| positive regulation of cellular protein metabolic process |
| regulation of cell population proliferation |
| negative regulation of response to stimulus |
| regulation of immune system process |
| regulation of cell death |
| positive regulation of protein metabolic process |
| regulation of intracellular signal transduction |
| regulation of protein modification process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Doxycycline 10μM R00 exp18 | -1.9 |
| Cycloheximide 0.2μM R00 exp15 | 1.91 |
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| HGC6.3 | 0.517 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 13473
- Expression level (log2 read counts): 6.98
Expression Distribution
MARCH7 Expression in NALM6 Cells: 6.98
