MARCKS

Entrez Summary: N/A
UniProt Summary: MARCKS is the most prominent cellular substrate for protein kinase C. This protein binds calmodulin, actin, and synapsin. MARCKS is a filamentous (F) actin cross-linking protein.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

germinal vesicle
actin crosslink formation
actin filament bundle
protein kinase C binding
actin filament bundle assembly
actin filament bundle organization
cell cortex
calmodulin binding
actin filament binding
actin cytoskeleton
actin filament organization
protein homooligomerization
focal adhesion
supramolecular fiber organization
centrosome
actin cytoskeleton organization
protein complex oligomerization
actin filament-based process
identical protein binding
cytoskeleton organization
protein-containing complex assembly
protein-containing complex subunit organization