MARCO [The Human Chemical-Genetic Interaction Map Project]

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======= MARCO =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MARCO
  * **<color #00a2e8>Official Name</color>**: macrophage receptor with collagenous structure
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8685|8685]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UEW3|Q9UEW3]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MARCO&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MARCO|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604870|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Pattern recognition receptor (PRR) which binds Gram- positive and Gram-negative bacteria (PubMed:9468508). Also plays a role in binding of unopsonized particles by alveolar macrophages (By similarity). Binds to the secretoglobin SCGB3A2 (PubMed:12847263). {ECO:0000250|UniProtKB:Q9WUB9, ECO:0000269|PubMed:12847263, ECO:0000269|PubMed:9468508}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Collagen|
|SRCR|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|signaling pattern recognition receptor activity|
|cargo receptor activity|
|amyloid-beta clearance|
|apoptotic cell clearance|
|scavenger receptor activity|
|collagen trimer|
|G protein-coupled receptor binding|
|endocytic vesicle membrane|
|amyloid-beta binding|
|adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway|
|pattern recognition receptor signaling pathway|
|phagocytosis, engulfment|
|transmembrane signaling receptor activity|
|plasma membrane invagination|
|membrane invagination|
|adenylate cyclase-modulating G protein-coupled receptor signaling pathway|
|positive regulation of ERK1 and ERK2 cascade|
|innate immune response-activating signal transduction|
|receptor-mediated endocytosis|
|G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|
|activation of innate immune response|
|regulation of ERK1 and ERK2 cascade|
|phagocytosis|
|positive regulation of innate immune response|
|positive regulation of response to biotic stimulus|
|regulation of innate immune response|
|positive regulation of defense response|
|positive regulation of multi-organism process|
|regulation of response to biotic stimulus|
|positive regulation of MAPK cascade|
|endocytosis|
|immune response-activating signal transduction|
|immune response-regulating signaling pathway|
|positive regulation of response to external stimulus|
|activation of immune response|
|import into cell|
|regulation of MAPK cascade|
|regulation of defense response|
|innate immune response|
|regulation of multi-organism process|
|membrane organization|
|positive regulation of immune response|
|defense response to other organism|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|positive regulation of phosphorylation|
|regulation of response to external stimulus|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|positive regulation of immune system process|
|regulation of immune response|
|positive regulation of protein modification process|
|response to other organism|
|response to external biotic stimulus|
|G protein-coupled receptor signaling pathway|
|response to biotic stimulus|
|defense response|
|integral component of plasma membrane|
|regulation of protein phosphorylation|
|regulation of response to stress|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|positive regulation of signal transduction|
|regulation of immune system process|
|positive regulation of protein metabolic process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|immune response|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp60|Vinblastine 0.002μM R01 exp60]]|-1.82|
|[[:results:exp519|RS-1 10μM R08 exp519]]|-1.73|
|[[:results:exp189|Temozolomide 200μM R04 exp189]]|-1.72|
|[[:results:exp316|Geldanamycin 0.015 to 0.025μM on day4 R07 exp316]]|1.71|
|[[:results:exp472|CI-1040 9.5μM R08 exp472]]|1.81|
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|1.91|
|[[:results:exp310|2-Methoxyestradiol 0.55μM R07 exp310]]|2|
|[[:results:exp418|Tunicamycin 0.04μM R07 exp418]]|2.03|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|2.12|
|[[:results:exp318|ABT-702 5μM R07 exp318]]|2.72|
|[[:results:exp410|THZ531 0.11 to 0.125μM on day4 R07 exp410]]|2.8|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9063
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MARCO Expression in NALM6 Cells: -7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>