MARVELD3

Gene Information

Official Symbol: MARVELD3
Official Name: MARVEL domain containing 3
Aliases and Previous Symbols: N/A
Entrez ID: 91862
UniProt: Q96A59
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: As a component of tight junctions, plays a role in paracellular ion conductivity. {ECO:0000269|PubMed:20028514}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 5177
Expression level (log2 read counts): 3.33

Expression Distribution

protein localization to cell junction
mitogen-activated protein kinase kinase kinase binding
bicellular tight junction assembly
negative regulation of JNK cascade
tight junction assembly
tight junction organization
apical junction assembly
negative regulation of stress-activated MAPK cascade
negative regulation of stress-activated protein kinase signaling cascade
negative regulation of epithelial cell migration
response to osmotic stress
cell-cell junction assembly
bicellular tight junction
negative regulation of epithelial cell proliferation
cell-cell junction organization
negative regulation of MAPK cascade
cell junction assembly
regulation of JNK cascade
cell junction organization
regulation of epithelial cell migration
regulation of stress-activated MAPK cascade
regulation of stress-activated protein kinase signaling cascade
cytoplasmic vesicle
negative regulation of cell migration
negative regulation of cell motility
negative regulation of cellular component movement
negative regulation of locomotion
regulation of epithelial cell proliferation
negative regulation of protein phosphorylation
negative regulation of phosphorylation
negative regulation of intracellular signal transduction
negative regulation of phosphate metabolic process
negative regulation of phosphorus metabolic process
negative regulation of protein modification process
negative regulation of cell population proliferation
regulation of cellular response to stress
regulation of MAPK cascade
regulation of cell migration
regulation of cell motility
regulation of locomotion