MAST2

Entrez Summary: N/A
UniProt Summary: Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins. Functions in a multi-protein complex in spermatid maturation. Regulates lipopolysaccharide-induced IL-12 synthesis in macrophages by forming a complex with TRAF6, resulting in the inhibition of TRAF6 NF-kappa-B activation (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

regulation of interleukin-12 biosynthetic process
phosphatase binding
regulation of interleukin-12 production
regulation of cytokine biosynthetic process
microtubule cytoskeleton
spermatid differentiation
peptidyl-serine phosphorylation
peptidyl-serine modification
magnesium ion binding
microtubule binding
cellular process involved in reproduction in multicellular organism
protein serine/threonine kinase activity
spermatogenesis
male gamete generation
developmental process involved in reproduction
gamete generation
regulation of cytokine production
multicellular organismal reproductive process
sexual reproduction
multicellular organism reproduction
peptidyl-amino acid modification
protein phosphorylation
multi-organism reproductive process
cytoskeleton organization
phosphorylation
reproductive process
reproduction
ATP binding
intracellular signal transduction