MAT2A [The Human Chemical-Genetic Interaction Map Project]

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======= MAT2A =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MAT2A
  * **<color #00a2e8>Official Name</color>**: methionine adenosyltransferase 2A
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4144|4144]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P31153|P31153]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MAT2A&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MAT2A|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601468|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene catalyzes the production of S-adenosylmethionine (AdoMet) from methionine and ATP. AdoMet is the key methyl donor in cellular processes. [provided by RefSeq, Jun 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Catalyzes the formation of S-adenosylmethionine from methionine and ATP. The reaction comprises two steps that are both catalyzed by the same enzyme: formation of S-adenosylmethionine (AdoMet) and triphosphate, and subsequent hydrolysis of the triphosphate. {ECO:0000269|PubMed:10644686, ECO:0000269|PubMed:23189196, ECO:0000269|PubMed:25075345}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|S-AdoMet synt C|
|S-AdoMet synt N|
|S-AdoMet synt M|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|methionine adenosyltransferase complex|
|methionine adenosyltransferase activity|
|S-adenosylmethionine biosynthetic process|
|protein hexamerization|
|S-adenosylmethionine metabolic process|
|one-carbon metabolic process|
|cellular response to leukemia inhibitory factor|
|response to leukemia inhibitory factor|
|protein heterooligomerization|
|coenzyme biosynthetic process|
|sulfur compound biosynthetic process|
|cofactor biosynthetic process|
|coenzyme metabolic process|
|methylation|
|sulfur compound metabolic process|
|cofactor metabolic process|
|drug metabolic process|
|protein complex oligomerization|
|cellular response to cytokine stimulus|
|identical protein binding|
|response to cytokine|
|ATP binding|
|protein-containing complex assembly|
|small molecule metabolic process|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp98|BI-6727 0.04μM R03 exp98]]|-2.6|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|-1.82|
|[[:results:exp134|MS023 2μM R03 exp134]]|-1.82|
|[[:results:exp94|Nocodazole 0.1μM R03 exp94]]|-1.82|
|[[:results:exp71|KU-0063794 3.8μM R02 exp71]]|-1.73|
|[[:results:exp346|CoCl2 18μM R07 exp346]]|1.7|
|[[:results:exp407|Thapsigargin 0.005μM R07 exp407]]|1.7|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|1.71|
|[[:results:exp18|Doxycycline 10μM R00 exp18]]|1.72|
|[[:results:exp393|Resminostat 0.5μM R07 exp393]]|1.77|
|[[:results:exp409|THZ531 0.11μM R07 exp409]]|1.77|
|[[:results:exp406|Thalidomide 20μM R07 exp406]]|1.79|
|[[:results:exp292|Menadione 5μM R06 exp292]]|1.81|
|[[:results:exp12|Chloramphenicol 2μM R00 exp12]]|1.82|
|[[:results:exp16|DABN 2μM R00 exp16]]|1.84|
|[[:results:exp237|NN-Diethyl-meta-toluamide 100μM R05 exp237]]|1.85|
|[[:results:exp60|Vinblastine 0.002μM R01 exp60]]|1.9|
|[[:results:exp177|Apcin 25μM plus proTAME 2μM R04 exp177]]|1.93|
|[[:results:exp38|Wortmannin 5μM R00 exp38]]|2|
|[[:results:exp41|BI-2536 0.001μM R01 exp41]]|2.02|
|[[:results:exp58|UM131593 0.1μM R01 exp58]]|2.09|
|[[:results:exp230|Epigallocatechin gallate 20μM R05 exp230]]|2.12|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.488|
|[[:human genes:p:polr2j3|POLR2J3]]|0.473|
|[[:human genes:c:cdca3|CDCA3]]|0.471|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.454|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.444|
|[[:human genes:c:ccna2|CCNA2]]|0.44|
|[[:human genes:d:dtl|DTL]]|0.439|
|[[:human genes:t:tceb3c|TCEB3C]]|0.437|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.435|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.434|
|[[:human genes:t:tfip11|TFIP11]]|0.428|
|[[:human genes:p:psmd3|PSMD3]]|0.426|
|[[:human genes:m:med17|MED17]]|0.425|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.421|
|[[:human genes:r:rad21|RAD21]]|0.417|
|[[:human genes:p:plk1|PLK1]]|0.416|
|[[:human genes:c:cdc45|CDC45]]|0.415|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.414|
|[[:human genes:f:fam20a|FAM20A]]|0.412|
|[[:human genes:p:polr2a|POLR2A]]|0.412|
|[[:human genes:d:dock6|DOCK6]]|0.412|
|[[:human genes:s:ssh2|SSH2]]|0.409|
|[[:human genes:d:ddtl|DDTL]]|0.409|
|[[:human genes:c:chd4|CHD4]]|0.407|
|[[:human genes:p:psmc6|PSMC6]]|0.405|
|[[:human genes:c:cgb2|CGB2]]|0.405|
|[[:human genes:p:psmb1|PSMB1]]|0.401|
|[[:human genes:c:ccdc94|CCDC94]]|0.401|
|[[:human genes:t:tsg101|TSG101]]|0.401|
|[[:human genes:c:c14orf93|C14orf93]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 494/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|1/1|
|bile duct|20/28|
|blood|24/28|
|bone|12/26|
|breast|28/33|
|central nervous system|25/56|
|cervix|2/4|
|colorectal|12/17|
|esophagus|10/13|
|fibroblast|0/1|
|gastric|11/16|
|kidney|14/21|
|liver|9/20|
|lung|55/75|
|lymphocyte|13/16|
|ovary|14/26|
|pancreas|20/24|
|peripheral nervous system|9/16|
|plasma cell|13/15|
|prostate|1/1|
|skin|17/24|
|soft tissue|5/9|
|thyroid|1/2|
|upper aerodigestive|15/22|
|urinary tract|14/29|
|uterus|3/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 496
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 9.71 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MAT2A Expression in NALM6 Cells: 9.71'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>