MAT2A

Entrez Summary: The protein encoded by this gene catalyzes the production of S-adenosylmethionine (AdoMet) from methionine and ATP. AdoMet is the key methyl donor in cellular processes. [provided by RefSeq, Jun 2011].
UniProt Summary: Catalyzes the formation of S-adenosylmethionine from methionine and ATP. The reaction comprises two steps that are both catalyzed by the same enzyme: formation of S-adenosylmethionine (AdoMet) and triphosphate, and subsequent hydrolysis of the triphosphate. {ECO:0000269|PubMed:10644686, ECO:0000269|PubMed:23189196, ECO:0000269|PubMed:25075345}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
BI-6727 0.04μM R03 exp98	-2.6
Hippuristanol 0.12μM R08 exp488	-1.82
MS023 2μM R03 exp134	-1.82
Nocodazole 0.1μM R03 exp94	-1.82
KU-0063794 3.8μM R02 exp71	-1.73
CoCl2 18μM R07 exp346	1.7
Thapsigargin 0.005μM R07 exp407	1.7
TRAIL 50ng/ml R00 exp36	1.71
Doxycycline 10μM R00 exp18	1.72
Resminostat 0.5μM R07 exp393	1.77
THZ531 0.11μM R07 exp409	1.77
Thalidomide 20μM R07 exp406	1.79
Menadione 5μM R06 exp292	1.81
Chloramphenicol 2μM R00 exp12	1.82
DABN 2μM R00 exp16	1.84
NN-Diethyl-meta-toluamide 100μM R05 exp237	1.85
Vinblastine 0.002μM R01 exp60	1.9
Apcin 25μM plus proTAME 2μM R04 exp177	1.93
Wortmannin 5μM R00 exp38	2
BI-2536 0.001μM R01 exp41	2.02
UM131593 0.1μM R01 exp58	2.09
Epigallocatechin gallate 20μM R05 exp230	2.12

Global Fraction of Cell Lines Where Essential: 494/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	1/1
bile duct	20/28
blood	24/28
bone	12/26
breast	28/33
central nervous system	25/56
cervix	2/4
colorectal	12/17
esophagus	10/13
fibroblast	0/1
gastric	11/16
kidney	14/21
liver	9/20
lung	55/75
lymphocyte	13/16
ovary	14/26
pancreas	20/24
peripheral nervous system	9/16
plasma cell	13/15
prostate	1/1
skin	17/24
soft tissue	5/9
thyroid	1/2
upper aerodigestive	15/22
urinary tract	14/29
uterus	3/5

Expression Distribution

methionine adenosyltransferase complex
methionine adenosyltransferase activity
S-adenosylmethionine biosynthetic process
protein hexamerization
S-adenosylmethionine metabolic process
one-carbon metabolic process
cellular response to leukemia inhibitory factor
response to leukemia inhibitory factor
protein heterooligomerization
coenzyme biosynthetic process
sulfur compound biosynthetic process
cofactor biosynthetic process
coenzyme metabolic process
methylation
sulfur compound metabolic process
cofactor metabolic process
drug metabolic process
protein complex oligomerization
cellular response to cytokine stimulus
identical protein binding
response to cytokine
ATP binding
protein-containing complex assembly
small molecule metabolic process
protein-containing complex subunit organization