MATR3 [The Human Chemical-Genetic Interaction Map Project]

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======= MATR3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MATR3
  * **<color #00a2e8>Official Name</color>**: matrin 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9782|9782]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P43243|P43243]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MATR3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MATR3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/164015|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a nuclear matrix protein, which is proposed to stabilize certain messenger RNA species. Mutations of this gene are associated with distal myopathy 2, which often includes vocal cord and pharyngeal weakness. Alternatively spliced transcript variants, including read-through transcripts composed of the upstream small nucleolar RNA host gene 4 (non-protein coding) and matrin 3 gene sequence, have been identified. Pseudogenes of this gene are located on chromosomes 1 and X. [provided by RefSeq, Aug 2013]. 
  * **<color #00a2e8>UniProt Summary</color>**:  May play a role in transcription or may interact with other nuclear matrix proteins to form the internal fibrogranular network. In association with the SFPQ-NONO heteromer may play a role in nuclear retention of defective RNAs. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). May bind to specific miRNA hairpins (PubMed:28431233). {ECO:0000269|PubMed:11525732, ECO:0000269|PubMed:28431233, ECO:0000269|PubMed:28712728}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|miRNA binding|
|nuclear inner membrane|
|heart valve development|
|ventricular septum development|
|nuclear matrix|
|cardiac septum development|
|cardiac ventricle development|
|cardiac chamber development|
|structural molecule activity|
|activation of innate immune response|
|positive regulation of innate immune response|
|positive regulation of response to biotic stimulus|
|regulation of innate immune response|
|positive regulation of defense response|
|positive regulation of multi-organism process|
|regulation of response to biotic stimulus|
|posttranscriptional regulation of gene expression|
|heart development|
|positive regulation of response to external stimulus|
|activation of immune response|
|regulation of defense response|
|innate immune response|
|regulation of multi-organism process|
|zinc ion binding|
|positive regulation of immune response|
|circulatory system development|
|defense response to other organism|
|identical protein binding|
|regulation of response to external stimulus|
|positive regulation of immune system process|
|regulation of immune response|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|RNA binding|
|regulation of response to stress|
|regulation of immune system process|
|immune response|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|-2.15|
|[[:results:exp410|THZ531 0.11 to 0.125μM on day4 R07 exp410]]|-2.1|
|[[:results:exp413|THZ531 0.11 to 0.175μM on day4 R07 exp413]]|-1.99|
|[[:results:exp226|Cerivastatin 0.15μM R05 exp226]]|-1.89|
|[[:results:exp497|Lead acetate 2000μM R08 exp497]]|-1.87|
|[[:results:exp502|Milciclib 2μM R08 exp502]]|-1.81|
|[[:results:exp514|Phorbol-12-myristate-13-acetate 0.57μM R08 exp514]]|-1.79|
|[[:results:exp47|Lapatinib 5μM R01 exp47]]|-1.76|
|[[:results:exp494|Isoniazid 100μM R08 exp494]]|-1.74|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|-1.7|
|[[:results:exp505|ML-792 0.2μM R08 exp505]]|1.73|
|[[:results:exp382|Palbociclib 1μM R07 exp382]]|1.75|
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|2|
|[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|2.1|
|[[:results:exp288|HMS-I2 10μM R06 exp288]]|2.12|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|2.13|
|[[:results:exp211|AICAR 240μM R05 exp211]]|2.27|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|2.53|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2411
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 9.27 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MATR3 Expression in NALM6 Cells: 9.27'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>