MATR3

Entrez Summary: This gene encodes a nuclear matrix protein, which is proposed to stabilize certain messenger RNA species. Mutations of this gene are associated with distal myopathy 2, which often includes vocal cord and pharyngeal weakness. Alternatively spliced transcript variants, including read-through transcripts composed of the upstream small nucleolar RNA host gene 4 (non-protein coding) and matrin 3 gene sequence, have been identified. Pseudogenes of this gene are located on chromosomes 1 and X. [provided by RefSeq, Aug 2013].
UniProt Summary: May play a role in transcription or may interact with other nuclear matrix proteins to form the internal fibrogranular network. In association with the SFPQ-NONO heteromer may play a role in nuclear retention of defective RNAs. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). May bind to specific miRNA hairpins (PubMed:28431233). {ECO:0000269|PubMed:11525732, ECO:0000269|PubMed:28431233, ECO:0000269|PubMed:28712728}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
JQ1 0.8μM R08 exp435	-2.15
THZ531 0.11 to 0.125μM on day4 R07 exp410	-2.1
THZ531 0.11 to 0.175μM on day4 R07 exp413	-1.99
Cerivastatin 0.15μM R05 exp226	-1.89
Lead acetate 2000μM R08 exp497	-1.87
Milciclib 2μM R08 exp502	-1.81
Phorbol-12-myristate-13-acetate 0.57μM R08 exp514	-1.79
Lapatinib 5μM R01 exp47	-1.76
Isoniazid 100μM R08 exp494	-1.74
SNS-032 15μM R08 exp443	-1.7
ML-792 0.2μM R08 exp505	1.73
Palbociclib 1μM R07 exp382	1.75
Trimetrexate 0.03μM R08 exp535	2
Latrunculin-B 10μM R07 exp374	2.1
HMS-I2 10μM R06 exp288	2.12
Olaparib 4μM R08 exp512	2.13
AICAR 240μM R05 exp211	2.27
Bortezomib 0.005μM R00 exp6	2.53

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

miRNA binding
nuclear inner membrane
heart valve development
ventricular septum development
nuclear matrix
cardiac septum development
cardiac ventricle development
cardiac chamber development
structural molecule activity
activation of innate immune response
positive regulation of innate immune response
positive regulation of response to biotic stimulus
regulation of innate immune response
positive regulation of defense response
positive regulation of multi-organism process
regulation of response to biotic stimulus
posttranscriptional regulation of gene expression
heart development
positive regulation of response to external stimulus
activation of immune response
regulation of defense response
innate immune response
regulation of multi-organism process
zinc ion binding
positive regulation of immune response
circulatory system development
defense response to other organism
identical protein binding
regulation of response to external stimulus
positive regulation of immune system process
regulation of immune response
response to other organism
response to external biotic stimulus
response to biotic stimulus
defense response
RNA binding
regulation of response to stress
regulation of immune system process
immune response
membrane