MC4R

Entrez Summary: The protein encoded by this gene is a membrane-bound receptor and member of the melanocortin receptor family. The encoded protein interacts with adrenocorticotropic and MSH hormones and is mediated by G proteins. This is an intronless gene. Defects in this gene are a cause of autosomal dominant obesity. [provided by RefSeq, Jan 2010].
UniProt Summary: Receptor specific to the heptapeptide core common to adrenocorticotropic hormone and alpha-, beta-, and gamma-MSH. Plays a central role in energy homeostasis and somatic growth. This receptor is mediated by G proteins that stimulate adenylate cyclase (cAMP). {ECO:0000269|PubMed:12646665, ECO:0000269|PubMed:25163632}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

7TM GPCR Srsx
7tm 1

melanocyte-stimulating hormone receptor activity
melanocortin receptor activity
regulation of grooming behavior
negative regulation of feeding behavior
diet induced thermogenesis
negative regulation of behavior
positive regulation of bone remodeling
positive regulation of bone resorption
adaptive thermogenesis
neuropeptide binding
response to dietary excess
regulation of feeding behavior
positive regulation of tissue remodeling
insulin secretion
peptide hormone binding
regulation of bone resorption
regulation of bone remodeling
peptide hormone secretion
energy reserve metabolic process
regulation of behavior
hormone secretion
regulation of tissue remodeling
hormone transport
feeding behavior
adenylate cyclase-activating G protein-coupled receptor signaling pathway
cAMP-mediated signaling
protein secretion
establishment of protein localization to extracellular region
protein localization to extracellular region
signal release
cyclic-nucleotide-mediated signaling
peptide secretion
adenylate cyclase-modulating G protein-coupled receptor signaling pathway
response to insulin
energy derivation by oxidation of organic compounds
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
ubiquitin protein ligase binding
second-messenger-mediated signaling
response to peptide hormone
generation of precursor metabolites and energy