MCCC1

Entrez Summary: This gene encodes the large subunit of 3-methylcrotonyl-CoA carboxylase. This enzyme functions as a heterodimer and catalyzes the carboxylation of 3-methylcrotonyl-CoA to form 3-methylglutaconyl-CoA. Mutations in this gene are associated with 3-Methylcrotonylglycinuria, an autosomal recessive disorder of leucine catabolism. [provided by RefSeq, Jul 2008].
UniProt Summary: Biotin-attachment subunit of the 3-methylcrotonyl-CoA carboxylase, an enzyme that catalyzes the conversion of 3- methylcrotonyl-CoA to 3-methylglutaconyl-CoA, a critical step for leucine and isovaleric acid catabolism. {ECO:0000269|PubMed:17360195}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Docetaxel 0.001 to 0.002μM on day4 R04 exp159	-1.8
ABT-702 5μM plus CoCl2 18μM R07 exp320	-1.77

methylcrotonoyl-CoA carboxylase complex
methylcrotonoyl-CoA carboxylase activity
3-methylcrotonyl-CoA carboxylase complex, mitochondrial
biotin carboxylase activity
biotin binding
leucine catabolic process
leucine metabolic process
biotin metabolic process
branched-chain amino acid catabolic process
branched-chain amino acid metabolic process
water-soluble vitamin metabolic process
alpha-amino acid catabolic process
protein heterooligomerization
vitamin metabolic process
cellular amino acid catabolic process
alpha-amino acid metabolic process
coenzyme metabolic process
carboxylic acid catabolic process
organic acid catabolic process
cellular amino acid metabolic process
sulfur compound metabolic process
mitochondrial matrix
small molecule catabolic process
cofactor metabolic process
drug metabolic process
protein complex oligomerization
monocarboxylic acid metabolic process
cellular amide metabolic process
carboxylic acid metabolic process
oxoacid metabolic process
organic acid metabolic process
organonitrogen compound catabolic process
mitochondrion
ATP binding
protein-containing complex assembly
small molecule metabolic process
organic substance catabolic process
cellular catabolic process
protein-containing complex subunit organization