MCL1 [The Human Chemical-Genetic Interaction Map Project]

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======= MCL1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MCL1
  * **<color #00a2e8>Official Name</color>**: MCL1 apoptosis regulator, BCL2 family member
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4170|4170]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q07820|Q07820]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MCL1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MCL1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/159552|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes an anti-apoptotic protein, which is a member of the Bcl-2 family. Alternative splicing results in multiple transcript variants. The longest gene product (isoform 1) enhances cell survival by inhibiting apoptosis while the alternatively spliced shorter gene products (isoform 2 and isoform 3) promote apoptosis and are death-inducing. [provided by RefSeq, Oct 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Bcl-2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway|
|positive regulation of oxidative stress-induced neuron death|
|BH3 domain binding|
|Bcl-2 family protein complex|
|positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway|
|regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway|
|positive regulation of oxidative stress-induced cell death|
|positive regulation of cellular response to oxidative stress|
|negative regulation of anoikis|
|positive regulation of response to oxidative stress|
|protein transmembrane transporter activity|
|regulation of anoikis|
|regulation of oxidative stress-induced neuron death|
|regulation of oxidative stress-induced intrinsic apoptotic signaling pathway|
|signal transduction in absence of ligand|
|extrinsic apoptotic signaling pathway in absence of ligand|
|negative regulation of signal transduction in absence of ligand|
|negative regulation of extrinsic apoptotic signaling pathway in absence of ligand|
|cell fate determination|
|regulation of extrinsic apoptotic signaling pathway in absence of ligand|
|positive regulation of neuron apoptotic process|
|positive regulation of intrinsic apoptotic signaling pathway|
|protein transmembrane transport|
|regulation of oxidative stress-induced cell death|
|intrinsic apoptotic signaling pathway in response to DNA damage|
|regulation of cellular response to oxidative stress|
|negative regulation of autophagy|
|regulation of response to oxidative stress|
|positive regulation of neuron death|
|negative regulation of intrinsic apoptotic signaling pathway|
|extrinsic apoptotic signaling pathway|
|negative regulation of extrinsic apoptotic signaling pathway|
|intrinsic apoptotic signaling pathway|
|regulation of extrinsic apoptotic signaling pathway|
|regulation of intrinsic apoptotic signaling pathway|
|mitochondrial outer membrane|
|positive regulation of apoptotic signaling pathway|
|regulation of neuron apoptotic process|
|regulation of response to DNA damage stimulus|
|negative regulation of apoptotic signaling pathway|
|cell fate commitment|
|negative regulation of cellular catabolic process|
|apoptotic signaling pathway|
|negative regulation of catabolic process|
|regulation of neuron death|
|regulation of autophagy|
|regulation of apoptotic signaling pathway|
|protein heterodimerization activity|
|negative regulation of intracellular signal transduction|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|cytokine-mediated signaling pathway|
|positive regulation of cell death|
|regulation of cellular response to stress|
|cellular response to DNA damage stimulus|
|regulation of cellular catabolic process|
|protein homodimerization activity|
|negative regulation of apoptotic process|
|cellular homeostasis|
|negative regulation of programmed cell death|
|apoptotic process|
|regulation of catabolic process|
|negative regulation of cell death|
|cellular response to cytokine stimulus|
|positive regulation of intracellular signal transduction|
|programmed cell death|
|cell death|
|response to cytokine|
|mitochondrion|
|negative regulation of signal transduction|
|transmembrane transport|
|negative regulation of cell communication|
|negative regulation of signaling|
|regulation of response to stress|
|protein transport|
|peptide transport|
|regulation of apoptotic process|
|regulation of programmed cell death|
|amide transport|
|establishment of protein localization|
|negative regulation of response to stimulus|
|homeostatic process|
|positive regulation of signal transduction|
|regulation of cell death|
|intracellular signal transduction|
|cellular response to stress|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|nitrogen compound transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp214|2-Deoxy-D-glucose 800μM R05 exp214]]|1.72|
|[[:results:exp303|39°C R06 exp303]]|1.74|
|[[:results:exp232|Epothilone-D 0.004 to 0.006μM on day4 R05 exp232]]|1.78|
|[[:results:exp420|Tunicamycin 0.04 to 0.125μM  on day4 R07 exp420]]|1.8|
|[[:results:exp480|ETC-159 50μM R08 exp480]]|1.83|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|1.92|
|[[:results:exp514|Phorbol-12-myristate-13-acetate 0.57μM R08 exp514]]|1.92|
|[[:results:exp363|GSK-J4 1-1.25μM to day4 R07 exp363]]|2.01|
|[[:results:exp85|UM0129480 7μM R02 exp85]]|2.01|
|[[:results:exp52|Ribavirin 10μM R01 exp52]]|2.02|
|[[:results:exp407|Thapsigargin 0.005μM R07 exp407]]|2.08|
|[[:results:exp218|A-395 10μM R05 exp218]]|2.12|
|[[:results:exp355|Dinaciclib 0.007μM R07 exp355]]|2.12|
|[[:results:exp61|YM155 0.0002μM R01 exp61]]|2.12|
|[[:results:exp179|Combretastatin A4 0.002 to 0.003μM day4 R04 exp179]]|2.17|
|[[:results:exp229|Dimethyloxaloylglycine 100μM R05 exp229]]|2.17|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|2.23|
|[[:results:exp162|BI-D1870 2μM R04 exp162]]|2.26|
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|2.42|
|[[:results:exp356|Docosahexaenoic-acid 50μM R07 exp356]]|2.43|
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|2.46|
|[[:results:exp227|Cryptotanshinone 12μM R05 exp227]]|2.46|
|[[:results:exp528|TGF-beta1 44ng/ml R08 exp528]]|2.54|
|[[:results:exp116|AICAR 240μM R03 exp116]]|2.56|
|[[:results:exp38|Wortmannin 5μM R00 exp38]]|2.57|
|[[:results:exp225|Celastrol 0.12μM R05 exp225]]|2.66|
|[[:results:exp80|RO-3307 4.7μM R02 exp80]]|2.67|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|2.74|
|[[:results:exp233|EPZ-5676 30μM R05 exp233]]|2.74|
|[[:results:exp243|S-trityl-L-cysteine 0.5μM R05 exp243]]|2.78|
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|3.46|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|4.09|
|[[:results:exp456|Benzoate 20000μM R08 exp456]]|4.44|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:m:march5|MARCH5]]|0.424|
|[[:human genes:v:vdac2|VDAC2]]|0.421|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 141/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|1/28|
|blood|12/28|
|bone|7/26|
|breast|11/33|
|central nervous system|11/56|
|cervix|0/4|
|colorectal|3/17|
|esophagus|1/13|
|fibroblast|0/1|
|gastric|2/16|
|kidney|0/21|
|liver|6/20|
|lung|8/75|
|lymphocyte|8/16|
|ovary|2/26|
|pancreas|0/24|
|peripheral nervous system|3/16|
|plasma cell|9/15|
|prostate|1/1|
|skin|3/24|
|soft tissue|1/9|
|thyroid|0/2|
|upper aerodigestive|5/22|
|urinary tract|3/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 620
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.98 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MCL1 Expression in NALM6 Cells: 7.98'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>