MCM10

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
BN82002 4μM R07 exp340	1.71
UMK57 0.6μM R03 exp107	1.74
GSK-J5 1.5μM R08 exp484	1.75
Demecolcine 0.03μM R05 exp228	1.8
Geldanamycin 0.015 to 0.025μM on day4 R07 exp316	2.24

Global Fraction of Cell Lines Where Essential: 3/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	1/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	1/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Gene	Correlation
POLR2J3	0.435
DTL	0.412

zf-primase
Mcm10

replication fork protection complex
DNA replication origin binding
DNA replication initiation
double-stranded DNA binding
single-stranded DNA binding
G1/S transition of mitotic cell cycle
DNA-dependent DNA replication
cell cycle G1/S phase transition
DNA replication
mitotic cell cycle phase transition
cell cycle phase transition
enzyme binding
cell population proliferation
mitotic cell cycle process
mitotic cell cycle
DNA metabolic process
cellular response to DNA damage stimulus
nucleolus
cell cycle process
identical protein binding
cell cycle
cellular response to stress
cellular macromolecule biosynthetic process
macromolecule biosynthetic process