MCPH1

Entrez Summary: This gene encodes a DNA damage response protein. The encoded protein may play a role in G2/M checkpoint arrest via maintenance of inhibitory phosphorylation of cyclin-dependent kinase 1. Mutations in this gene have been associated with primary autosomal recessive microcephaly 1 and premature chromosome condensation syndrome. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2010].
UniProt Summary: Implicated in chromosome condensation and DNA damage induced cellular responses. May play a role in neurogenesis and regulation of the size of the cerebral cortex. {ECO:0000269|PubMed:12046007, ECO:0000269|PubMed:15199523, ECO:0000269|PubMed:15220350}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
BI-6727 0.0125μM R03 exp97	-1.99
UMK57 0.6μM R03 exp107	-1.81

regulation of chromosome condensation
mitotic cell cycle arrest
protein localization to microtubule organizing center
protein localization to centrosome
neuronal stem cell population maintenance
establishment of mitotic spindle orientation
establishment of mitotic spindle localization
protein localization to microtubule cytoskeleton
establishment of spindle orientation
protein localization to cytoskeleton
establishment of spindle localization
spindle localization
regulation of centrosome cycle
microtubule cytoskeleton organization involved in mitosis
cerebral cortex development
establishment of cell polarity
stem cell population maintenance
maintenance of cell number
cell cycle arrest
microtubule organizing center
pallium development
regulation of microtubule cytoskeleton organization
establishment or maintenance of cell polarity
bone development
regulation of microtubule-based process
telencephalon development
negative regulation of mitotic cell cycle
regulation of inflammatory response
regulation of chromosome organization
establishment of organelle localization
forebrain development
microtubule cytoskeleton organization
skeletal system development
regulation of cytoskeleton organization
negative regulation of cell cycle
organelle localization
mitotic cell cycle process
regulation of mitotic cell cycle
microtubule-based process
mitotic cell cycle