MCRS1

Entrez Summary: N/A
UniProt Summary: Modulates the transcription repressor activity of DAXX by recruiting it to the nucleolus (PubMed:11948183). As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues (PubMed:20018852). Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. May also be an inhibitor of TERT telomerase activity (PubMed:15044100). Binds to G-quadruplex structures in mRNA (PubMed:16571602). Binds to RNA homopolymer poly(G) and poly(U) (PubMed:16571602). {ECO:0000269|PubMed:11948183, ECO:0000269|PubMed:15044100, ECO:0000269|PubMed:16571602, ECO:0000269|PubMed:20018852}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 2/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	1/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	1/29
uterus	0/5

Expression Distribution

Screen	Score
GSK461364A 0.005μM R03 exp125	1.7
Tubastatin-A 2.5μM R07 exp417	1.76

positive regulation of protein localization to nucleolus
NSL complex
G-quadruplex RNA binding
regulation of protein localization to nucleolus
poly(G) binding
histone acetyltransferase activity (H4-K8 specific)
histone acetyltransferase activity (H4-K5 specific)
histone acetyltransferase activity (H4-K16 specific)
histone H4-K5 acetylation
Ino80 complex
histone H4-K8 acetylation
histone H4-K16 acetylation
histone acetyltransferase complex
poly(U) RNA binding
MLL1 complex
polysome
histone H4 acetylation
positive regulation of protein localization to nucleus
histone acetylation
regulation of protein localization to nucleus
internal peptidyl-lysine acetylation
peptidyl-lysine acetylation
internal protein amino acid acetylation
perikaryon
protein acetylation
protein acylation
DNA recombination
protein deubiquitination
protein modification by small protein removal
peptidyl-lysine modification
positive regulation of cellular protein localization
histone modification
covalent chromatin modification
dendrite
DNA repair
regulation of cellular protein localization
chromatin organization
DNA metabolic process
cellular response to DNA damage stimulus
nucleolus