MCTP1

Entrez Summary: N/A
UniProt Summary: Calcium sensor which is essential for the stabilization of normal baseline neurotransmitter release and for the induction and long-term maintenance of presynaptic homeostatic plasticity. {ECO:0000250|UniProtKB:A1ZBD6}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	1/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

C2
PRT C

negative regulation of endocytosis
negative regulation of response to oxidative stress
regulation of neuronal synaptic plasticity
calcium-dependent phospholipid binding
synaptic vesicle membrane
regulation of response to oxidative stress
regulation of neurotransmitter secretion
recycling endosome
regulation of neurotransmitter transport
calcium-mediated signaling
regulation of synaptic plasticity
regulation of endocytosis
negative regulation of cell migration
negative regulation of cell motility
negative regulation of cellular component movement
negative regulation of locomotion
second-messenger-mediated signaling
regulation of neurotransmitter levels
modulation of chemical synaptic transmission
regulation of trans-synaptic signaling
negative regulation of transport
cell junction
regulation of vesicle-mediated transport
negative regulation of cellular component organization
calcium ion binding
regulation of secretion by cell
regulation of secretion
regulation of cell migration
regulation of cell motility
regulation of cellular localization
endoplasmic reticulum membrane
regulation of locomotion
regulation of cellular component movement
regulation of response to stress
negative regulation of response to stimulus
intracellular signal transduction
regulation of transport