MCU

Gene Information

Official Symbol: MCU
Official Name: mitochondrial calcium uniporter
Aliases and Previous Symbols: N/A
Entrez ID: 90550
UniProt: Q8NE86
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondria (PubMed:21685888, PubMed:21685886, PubMed:23101630, PubMed:22904319, PubMed:23178883, PubMed:22829870, PubMed:22822213, PubMed:24332854, PubMed:23755363, PubMed:26341627). Constitutes the pore-forming and calcium-conducting subunit of the uniporter complex (uniplex) (PubMed:23755363). Activity is regulated by MICU1 and MICU2. At low Ca(2+) levels MCU activity is down- regulated by MICU1 and MICU2; at higher Ca(2+) levels MICU1 increases MCU activity (PubMed:24560927, PubMed:26903221). Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways. Involved in buffering the amplitude of systolic calcium rises in cardiomyocytes (PubMed:22822213). While dispensable for baseline homeostatic cardiac function, acts as a key regulator of short- term mitochondrial calcium loading underlying a 'fight-or-flight' response during acute stress: acts by mediating a rapid increase of mitochondrial calcium in pacemaker cells (PubMed:25603276). participates in mitochondrial permeability transition during ischemia-reperfusion injury (By similarity). Regulates glucose- dependent insulin secretion in pancreatic beta-cells by regulating mitochondrial calcium uptake (PubMed:22904319, PubMed:22829870). Mitochondrial calcium uptake in skeletal muscle cells is involved in muscle size in adults (By similarity). Regulates synaptic vesicle endocytosis kinetics in central nerve terminal (By similarity). Involved in antigen processing and presentation (By similarity). {ECO:0000250|UniProtKB:Q3UMR5, ECO:0000269|PubMed:21685886, ECO:0000269|PubMed:21685888, ECO:0000269|PubMed:22822213, ECO:0000269|PubMed:22829870, ECO:0000269|PubMed:22904319, ECO:0000269|PubMed:23101630, ECO:0000269|PubMed:23178883, ECO:0000269|PubMed:23755363, ECO:0000269|PubMed:24332854, ECO:0000269|PubMed:24560927, ECO:0000269|PubMed:25603276, ECO:0000269|PubMed:26341627, ECO:0000269|PubMed:26903221}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	1/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 15735
Expression level (log2 read counts): 5.52

Expression Distribution

Screen	Score
BVD-523 15μM R02 exp67	-1.73
Vinblastine 0.002μM R01 exp60	1.93

uniporter activity
uniplex complex
calcium import into the mitochondrion
positive regulation of mitochondrial calcium ion concentration
mitochondrial calcium ion transmembrane transport
calcium channel complex
mitochondrial calcium ion homeostasis
integral component of mitochondrial inner membrane
calcium ion import
calcium channel activity
positive regulation of insulin secretion
cytosolic calcium ion transport
mitochondrial transmembrane transport
positive regulation of peptide hormone secretion
positive regulation of hormone secretion
calcium-mediated signaling
regulation of insulin secretion
glucose homeostasis
carbohydrate homeostasis
calcium ion transmembrane transport
regulation of peptide hormone secretion
mitochondrial transport
calcium ion transport
regulation of hormone secretion
positive regulation of protein secretion
positive regulation of peptide secretion
divalent metal ion transport
divalent inorganic cation transport
second-messenger-mediated signaling
mitochondrial inner membrane
positive regulation of secretion by cell
positive regulation of protein transport
positive regulation of secretion
cellular calcium ion homeostasis
calcium ion homeostasis
positive regulation of establishment of protein localization
regulation of protein secretion
cellular divalent inorganic cation homeostasis
divalent inorganic cation homeostasis
regulation of peptide secretion