MED16 [The Human Chemical-Genetic Interaction Map Project]

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======= MED16 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MED16
  * **<color #00a2e8>Official Name</color>**: mediator complex subunit 16
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10025|10025]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y2X0|Q9Y2X0]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MED16&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MED16|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604062|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. {ECO:0000269|PubMed:10198638, ECO:0000269|PubMed:10235266}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|WD40|
|Med16|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|thyroid hormone receptor coactivator activity|
|vitamin D receptor binding|
|thyroid hormone receptor binding|
|mediator complex|
|catalytic activity|
|transcription coregulator activity|
|transcription initiation from RNA polymerase II promoter|
|DNA-templated transcription, initiation|
|transcription coactivator activity|
|transcription by RNA polymerase II|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|organic cyclic compound biosynthetic process|
|positive regulation of transcription, DNA-templated|
|cellular nitrogen compound biosynthetic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|positive regulation of RNA metabolic process|
|macromolecule biosynthetic process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|membrane|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp352|Dexamethasone 0.006 to 0.015μM on day4 R07 exp352]]|-2.4|
|[[:results:exp429|Rapamycin 0.001μM R08 exp429]]|-2|
|[[:results:exp229|Dimethyloxaloylglycine 100μM R05 exp229]]|-1.9|
|[[:results:exp405|Tenofovir 10μM R07 exp405]]|-1.85|
|[[:results:exp508|NN-Dimethylsphingosine 2.5μM R08 exp508]]|-1.84|
|[[:results:exp50|Nicotinamide 2000μM R01 exp50]]|-1.81|
|[[:results:exp301|VER-155008 3.9μM R06 exp301]]|-1.75|
|[[:results:exp334|All-trans-Retinoic-Acid 40μM R07 exp334]]|-1.7|
|[[:results:exp472|CI-1040 9.5μM R08 exp472]]|1.9|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|2.02|
|[[:results:exp108|Vinblastine 0.2μM R03 exp108]]|2.02|
|[[:results:exp256|HMS-I1 10μM R06 exp256]]|2.03|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|2.09|
|[[:results:exp244|SB743921 0.001μM R05 exp244]]|2.11|
|[[:results:exp64|Nocodazole 0.2μM R02 exp64]]|2.14|
|[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|2.22|
|[[:results:exp111|R-DABN 8μM R03 exp111]]|2.27|
|[[:results:exp126|GSK461364A 0.1μM R03 exp126]]|2.36|
|[[:results:exp24|Nocodazole 0.2μM R00 exp24]]|2.37|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|2.59|
|[[:results:exp94|Nocodazole 0.1μM R03 exp94]]|2.65|
|[[:results:exp208|Vinblastine 0.015μM R05 exp208]]|2.74|
|[[:results:exp487|Hinokiflavone 12μM R08 exp487]]|2.8|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|2.8|
|[[:results:exp96|BI-2536 0.02μM R03 exp96]]|3.12|
|[[:results:exp93|DABN racemic mixture R03 exp93]]|3.13|
|[[:results:exp448|Ammonium tetrathiomolybdate 10μM R08 exp448]]|3.19|
|[[:results:exp98|BI-6727 0.04μM R03 exp98]]|3.62|
|[[:results:exp459|Bleomycin 5μM R08 exp459]]|3.65|
|[[:results:exp199|Etoposide 0.3μM R05 exp199]]|3.66|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rnmt|RNMT]]|0.671|
|[[:human genes:d:dpagt1|DPAGT1]]|0.664|
|[[:human genes:t:tti2|TTI2]]|0.66|
|[[:human genes:c:ccdc101|CCDC101]]|0.655|
|[[:human genes:g:gnb1l|GNB1L]]|0.648|
|[[:human genes:p:pelo|PELO]]|0.643|
|[[:human genes:t:thg1l|THG1L]]|0.638|
|[[:human genes:t:tti1|TTI1]]|0.621|
|[[:human genes:r:rptor|RPTOR]]|0.614|
|[[:human genes:a:alg1|ALG1]]|0.601|
|[[:human genes:t:telo2|TELO2]]|0.598|
|[[:human genes:p:pmm2|PMM2]]|0.597|
|[[:human genes:m:med23|MED23]]|0.597|
|[[:human genes:g:gmppb|GMPPB]]|0.597|
|[[:human genes:b:bub3|BUB3]]|0.594|
|[[:human genes:r:rtcb|RTCB]]|0.588|
|[[:human genes:m:mllt1|MLLT1]]|0.583|
|[[:human genes:g:gtf3c2|GTF3C2]]|0.573|
|[[:human genes:w:wdr24|WDR24]]|0.571|
|[[:human genes:g:gfpt1|GFPT1]]|0.571|
|[[:human genes:a:adsl|ADSL]]|0.562|
|[[:human genes:a:aars|AARS]]|0.56|
|[[:human genes:v:vhl|VHL]]|0.556|
|[[:human genes:m:med4|MED4]]|0.554|
|[[:human genes:a:atxn10|ATXN10]]|0.55|
|[[:human genes:a:alg2|ALG2]]|0.543|
|[[:human genes:g:gtf3c4|GTF3C4]]|0.542|
|[[:human genes:a:alg13|ALG13]]|0.537|
|[[:human genes:t:tsen54|TSEN54]]|0.535|
|[[:human genes:c:cbfb|CBFB]]|0.533|
|[[:human genes:v:vmp1|VMP1]]|0.533|
|[[:human genes:t:triap1|TRIAP1]]|0.532|
|[[:human genes:d:dohh|DOHH]]|0.531|
|[[:human genes:o:oraov1|ORAOV1]]|0.529|
|[[:human genes:n:nae1|NAE1]]|0.522|
|[[:human genes:r:rpp21|RPP21]]|0.517|
|[[:human genes:p:pam16|PAM16]]|0.516|
|[[:human genes:m:mtor|MTOR]]|0.514|
|[[:human genes:d:dhps|DHPS]]|0.51|
|[[:human genes:d:dr1|DR1]]|0.509|
|[[:human genes:t:thoc6|THOC6]]|0.509|
|[[:human genes:z:zbtb11|ZBTB11]]|0.508|
|[[:human genes:d:dad1|DAD1]]|0.506|
|[[:human genes:m:mad2l1|MAD2L1]]|0.505|
|[[:human genes:h:haus8|HAUS8]]|0.501|
|[[:human genes:r:rbm14|RBM14]]|0.499|
|[[:human genes:d:ddost|DDOST]]|0.499|
|[[:human genes:f:fnta|FNTA]]|0.498|
|[[:human genes:a:atp5o|ATP5O]]|0.497|
|[[:human genes:u:uhrf1|UHRF1]]|0.497|
|[[:human genes:u:uap1|UAP1]]|0.496|
|[[:human genes:m:mapk14|MAPK14]]|0.495|
|[[:human genes:p:ppp4c|PPP4C]]|0.495|
|[[:human genes:s:srp14|SRP14]]|0.494|
|[[:human genes:a:atp5b|ATP5B]]|0.494|
|[[:human genes:s:slc35b1|SLC35B1]]|0.492|
|[[:human genes:s:srp68|SRP68]]|0.492|
|[[:human genes:t:tmem41b|TMEM41B]]|0.491|
|[[:human genes:o:osgep|OSGEP]]|0.489|
|[[:human genes:a:alg14|ALG14]]|0.488|
|[[:human genes:l:lsmd1|LSMD1]]|0.486|
|[[:human genes:u:ube3a|UBE3A]]|0.482|
|[[:human genes:w:wdr59|WDR59]]|0.481|
|[[:human genes:e:eprs|EPRS]]|0.481|
|[[:human genes:s:spcs2|SPCS2]]|0.48|
|[[:human genes:p:polr3h|POLR3H]]|0.479|
|[[:human genes:t:trnt1|TRNT1]]|0.479|
|[[:human genes:y:yars|YARS]]|0.478|
|[[:human genes:e:exoc4|EXOC4]]|0.477|
|[[:human genes:e:eif4e|EIF4E]]|0.477|
|[[:human genes:d:ddx20|DDX20]]|0.473|
|[[:human genes:t:tada1|TADA1]]|0.473|
|[[:human genes:u:ube2g2|UBE2G2]]|0.473|
|[[:human genes:c:csnk2b|CSNK2B]]|0.471|
|[[:human genes:d:dbr1|DBR1]]|0.47|
|[[:human genes:g:gtf3c3|GTF3C3]]|0.469|
|[[:human genes:b:bap1|BAP1]]|0.469|
|[[:human genes:t:tle4|TLE4]]|0.469|
|[[:human genes:a:atp5j|ATP5J]]|0.468|
|[[:human genes:r:rpn1|RPN1]]|0.468|
|[[:human genes:s:seh1l|SEH1L]]|0.467|
|[[:human genes:h:hspd1|HSPD1]]|0.465|
|[[:human genes:t:txnrd1|TXNRD1]]|0.464|
|[[:human genes:v:vezt|VEZT]]|0.463|
|[[:human genes:s:snapc5|SNAPC5]]|0.462|
|[[:human genes:r:rft1|RFT1]]|0.461|
|[[:human genes:w:wdr1|WDR1]]|0.46|
|[[:human genes:f:fh|FH]]|0.46|
|[[:human genes:u:utp23|UTP23]]|0.459|
|[[:human genes:f:fntb|FNTB]]|0.458|
|[[:human genes:t:trmt5|TRMT5]]|0.458|
|[[:human genes:s:srp72|SRP72]]|0.457|
|[[:human genes:m:max|MAX]]|0.456|
|[[:human genes:m:med25|MED25]]|0.455|
|[[:human genes:t:taf5l|TAF5L]]|0.455|
|[[:human genes:e:eny2|ENY2]]|0.455|
|[[:human genes:o:oip5|OIP5]]|0.454|
|[[:human genes:g:gpn2|GPN2]]|0.452|
|[[:human genes:e:exoc3|EXOC3]]|0.452|
|[[:human genes:u:uxt|UXT]]|0.451|
|[[:human genes:p:ppp2r3c|PPP2R3C]]|0.45|
|[[:human genes:w:wdr82|WDR82]]|0.45|
|[[:human genes:m:med18|MED18]]|0.449|
|[[:human genes:f:fli1|FLI1]]|0.448|
|[[:human genes:g:gemin8|GEMIN8]]|0.447|
|[[:human genes:d:dolk|DOLK]]|0.447|
|[[:human genes:a:alg5|ALG5]]|0.446|
|[[:human genes:p:pdap1|PDAP1]]|0.445|
|[[:human genes:l:lamtor5|LAMTOR5]]|0.445|
|[[:human genes:s:spcs3|SPCS3]]|0.445|
|[[:human genes:s:sdha|SDHA]]|0.444|
|[[:human genes:c:cdipt|CDIPT]]|0.444|
|[[:human genes:d:dctn6|DCTN6]]|0.444|
|[[:human genes:z:znf259|ZNF259]]|0.444|
|[[:human genes:z:zrsr2|ZRSR2]]|0.443|
|[[:human genes:t:tgs1|TGS1]]|0.442|
|[[:human genes:m:mad1l1|MAD1L1]]|0.441|
|[[:human genes:t:trmt10a|TRMT10A]]|0.44|
|[[:human genes:s:slc25a19|SLC25A19]]|0.44|
|[[:human genes:n:nars|NARS]]|0.439|
|[[:human genes:d:dnajc3|DNAJC3]]|0.439|
|[[:human genes:l:lsm11|LSM11]]|0.438|
|[[:human genes:d:dhx29|DHX29]]|0.436|
|[[:human genes:d:dicer1|DICER1]]|0.435|
|[[:human genes:p:pax5|PAX5]]|0.434|
|[[:human genes:s:ssbp2|SSBP2]]|0.434|
|[[:human genes:u:uba3|UBA3]]|0.431|
|[[:human genes:t:taf6l|TAF6L]]|0.43|
|[[:human genes:g:gtf3c6|GTF3C6]]|0.428|
|[[:human genes:b:btaf1|BTAF1]]|0.427|
|[[:human genes:t:tmed10|TMED10]]|0.426|
|[[:human genes:m:maml1|MAML1]]|0.426|
|[[:human genes:c:cct7|CCT7]]|0.426|
|[[:human genes:w:wdr92|WDR92]]|0.425|
|[[:human genes:p:polr3b|POLR3B]]|0.425|
|[[:human genes:t:tbcb|TBCB]]|0.424|
|[[:human genes:x:xpo6|XPO6]]|0.424|
|[[:human genes:t:tpk1|TPK1]]|0.423|
|[[:human genes:t:tamm41|TAMM41]]|0.423|
|[[:human genes:e:ercc2|ERCC2]]|0.421|
|[[:human genes:t:timm22|TIMM22]]|0.421|
|[[:human genes:d:derl2|DERL2]]|0.421|
|[[:human genes:g:gtf2a2|GTF2A2]]|0.42|
|[[:human genes:o:otud5|OTUD5]]|0.42|
|[[:human genes:d:dpf2|DPF2]]|0.418|
|[[:human genes:g:gemin5|GEMIN5]]|0.418|
|[[:human genes:m:meaf6|MEAF6]]|0.418|
|[[:human genes:p:pggt1b|PGGT1B]]|0.416|
|[[:human genes:w:wars|WARS]]|0.416|
|[[:human genes:t:tcf4|TCF4]]|0.416|
|[[:human genes:l:lmo2|LMO2]]|0.416|
|[[:human genes:g:ggnbp2|GGNBP2]]|0.415|
|[[:human genes:a:alg6|ALG6]]|0.414|
|[[:human genes:t:thoc3|THOC3]]|0.414|
|[[:human genes:a:atp5d|ATP5D]]|0.414|
|[[:human genes:e:elac2|ELAC2]]|0.414|
|[[:human genes:p:phb|PHB]]|0.414|
|[[:human genes:l:lsm10|LSM10]]|0.413|
|[[:human genes:i:irf2bp2|IRF2BP2]]|0.413|
|[[:human genes:m:med13|MED13]]|0.412|
|[[:human genes:a:actr10|ACTR10]]|0.41|
|[[:human genes:z:znf592|ZNF592]]|0.41|
|[[:human genes:t:tprkb|TPRKB]]|0.41|
|[[:human genes:t:ttc4|TTC4]]|0.409|
|[[:human genes:d:dhdds|DHDDS]]|0.408|
|[[:human genes:c:crcp|CRCP]]|0.407|
|[[:human genes:a:aasdhppt|AASDHPPT]]|0.407|
|[[:human genes:a:atp2a2|ATP2A2]]|0.407|
|[[:human genes:t:ten1|TEN1]]|0.407|
|[[:human genes:s:smarcd1|SMARCD1]]|0.407|
|[[:human genes:b:brd9|BRD9]]|0.406|
|[[:human genes:a:atf7ip|ATF7IP]]|0.405|
|[[:human genes:t:trim28|TRIM28]]|0.405|
|[[:human genes:s:scaf8|SCAF8]]|0.405|
|[[:human genes:m:mbtps2|MBTPS2]]|0.405|
|[[:human genes:m:med31|MED31]]|0.404|
|[[:human genes:c:cdc37|CDC37]]|0.402|
|[[:human genes:i:icmt|ICMT]]|0.402|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 2/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|1/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|1/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 30
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.4 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MED16 Expression in NALM6 Cells: 5.4'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>