MEGF8 [The Human Chemical-Genetic Interaction Map Project]

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======= MEGF8 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MEGF8
  * **<color #00a2e8>Official Name</color>**: multiple EGF like domains 8
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1954|1954]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q7Z7M0|Q7Z7M0]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MEGF8&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MEGF8|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604267|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a single-pass type I membrane protein of unknown function that contains several EGF-like domains, Kelch repeats, and PSI domains. Defects in this gene are a cause of Carpenter syndrome 2. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2012]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Laminin EGF|
|CUB|
|PSI|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|epiboly involved in gastrulation with mouth forming second|
|fasciculation of sensory neuron axon|
|embryonic heart tube left/right pattern formation|
|positive regulation of axon extension involved in axon guidance|
|determination of digestive tract left/right asymmetry|
|positive regulation of axon guidance|
|cell migration involved in gastrulation|
|craniofacial suture morphogenesis|
|left/right pattern formation|
|neuron projection fasciculation|
|axonal fasciculation|
|epiboly|
|gastrulation with mouth forming second|
|negative regulation of smoothened signaling pathway|
|regulation of axon extension involved in axon guidance|
|positive regulation of axon extension|
|regulation of axon guidance|
|coronary vasculature development|
|neuron recognition|
|morphogenesis of an epithelial sheet|
|embryonic heart tube morphogenesis|
|cranial skeletal system development|
|determination of heart left/right asymmetry|
|embryonic heart tube development|
|regulation of smoothened signaling pathway|
|positive regulation of axonogenesis|
|BMP signaling pathway|
|embryonic skeletal system morphogenesis|
|regulation of axon extension|
|response to BMP|
|cellular response to BMP stimulus|
|regulation of extent of cell growth|
|bone morphogenesis|
|determination of left/right symmetry|
|determination of bilateral symmetry|
|specification of symmetry|
|embryonic limb morphogenesis|
|embryonic appendage morphogenesis|
|embryonic skeletal system development|
|digestive tract development|
|positive regulation of chemotaxis|
|digestive system development|
|appendage morphogenesis|
|limb morphogenesis|
|positive regulation of cell morphogenesis involved in differentiation|
|gastrulation|
|positive regulation of cell growth|
|positive regulation of developmental growth|
|ameboidal-type cell migration|
|appendage development|
|limb development|
|regulation of cell size|
|regulation of axonogenesis|
|transmembrane receptor protein serine/threonine kinase signaling pathway|
|bone development|
|regulation of chemotaxis|
|skeletal system morphogenesis|
|cell recognition|
|heart morphogenesis|
|positive regulation of growth|
|positive regulation of neuron projection development|
|embryonic organ morphogenesis|
|regulation of cell morphogenesis involved in differentiation|
|epithelial tube morphogenesis|
|regulation of developmental growth|
|regionalization|
|positive regulation of neuron differentiation|
|regulation of cellular component size|
|positive regulation of cell projection organization|
|axon development|
|regulation of cell growth|
|morphogenesis of an epithelium|
|embryonic organ development|
|pattern specification process|
|positive regulation of neurogenesis|
|blood vessel development|
|regulation of cell morphogenesis|
|skeletal system development|
|regulation of neuron projection development|
|cellular response to growth factor stimulus|
|vasculature development|
|regulation of anatomical structure size|
|cardiovascular system development|
|heart development|
|response to growth factor|
|positive regulation of nervous system development|
|positive regulation of cellular component movement|
|positive regulation of cell development|
|positive regulation of locomotion|
|tissue morphogenesis|
|embryonic morphogenesis|
|positive regulation of response to external stimulus|
|chordate embryonic development|
|embryo development ending in birth or egg hatching|
|tube morphogenesis|
|regulation of neuron differentiation|
|neuron projection development|
|regulation of growth|
|regulation of plasma membrane bounded cell projection organization|
|regulation of cell projection organization|
|enzyme linked receptor protein signaling pathway|
|calcium ion binding|
|neuron development|
|regulation of neurogenesis|
|tube development|
|circulatory system development|
|regulation of nervous system development|
|regulation of cell development|
|animal organ morphogenesis|
|cell migration|
|positive regulation of cell differentiation|
|embryo development|
|regulation of locomotion|
|regulation of cellular component movement|
|neuron differentiation|
|regulation of anatomical structure morphogenesis|
|localization of cell|
|cell motility|
|regulation of response to external stimulus|
|epithelium development|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|positive regulation of cellular component organization|
|cellular response to endogenous stimulus|
|negative regulation of signal transduction|
|locomotion|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|response to endogenous stimulus|
|generation of neurons|
|movement of cell or subcellular component|
|negative regulation of response to stimulus|
|neurogenesis|
|cell development|
|positive regulation of multicellular organismal process|
|tissue development|
|regulation of cell differentiation|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp285|GW501516 25μM R06 exp285]]|-1.72|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3415
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.54 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MEGF8 Expression in NALM6 Cells: 6.54'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>