MEGF8
Gene Information
- Official Symbol: MEGF8
- Official Name: multiple EGF like domains 8
- Aliases and Previous Symbols: N/A
- Entrez ID: 1954
- UniProt: Q7Z7M0
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: The protein encoded by this gene is a single-pass type I membrane protein of unknown function that contains several EGF-like domains, Kelch repeats, and PSI domains. Defects in this gene are a cause of Carpenter syndrome 2. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2012].
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| Laminin EGF |
| CUB |
| PSI |
GO Terms
| epiboly involved in gastrulation with mouth forming second |
| fasciculation of sensory neuron axon |
| embryonic heart tube left/right pattern formation |
| positive regulation of axon extension involved in axon guidance |
| determination of digestive tract left/right asymmetry |
| positive regulation of axon guidance |
| cell migration involved in gastrulation |
| craniofacial suture morphogenesis |
| left/right pattern formation |
| neuron projection fasciculation |
| axonal fasciculation |
| epiboly |
| gastrulation with mouth forming second |
| negative regulation of smoothened signaling pathway |
| regulation of axon extension involved in axon guidance |
| positive regulation of axon extension |
| regulation of axon guidance |
| coronary vasculature development |
| neuron recognition |
| morphogenesis of an epithelial sheet |
| embryonic heart tube morphogenesis |
| cranial skeletal system development |
| determination of heart left/right asymmetry |
| embryonic heart tube development |
| regulation of smoothened signaling pathway |
| positive regulation of axonogenesis |
| BMP signaling pathway |
| embryonic skeletal system morphogenesis |
| regulation of axon extension |
| response to BMP |
| cellular response to BMP stimulus |
| regulation of extent of cell growth |
| bone morphogenesis |
| determination of left/right symmetry |
| determination of bilateral symmetry |
| specification of symmetry |
| embryonic limb morphogenesis |
| embryonic appendage morphogenesis |
| embryonic skeletal system development |
| digestive tract development |
| positive regulation of chemotaxis |
| digestive system development |
| appendage morphogenesis |
| limb morphogenesis |
| positive regulation of cell morphogenesis involved in differentiation |
| gastrulation |
| positive regulation of cell growth |
| positive regulation of developmental growth |
| ameboidal-type cell migration |
| appendage development |
| limb development |
| regulation of cell size |
| regulation of axonogenesis |
| transmembrane receptor protein serine/threonine kinase signaling pathway |
| bone development |
| regulation of chemotaxis |
| skeletal system morphogenesis |
| cell recognition |
| heart morphogenesis |
| positive regulation of growth |
| positive regulation of neuron projection development |
| embryonic organ morphogenesis |
| regulation of cell morphogenesis involved in differentiation |
| epithelial tube morphogenesis |
| regulation of developmental growth |
| regionalization |
| positive regulation of neuron differentiation |
| regulation of cellular component size |
| positive regulation of cell projection organization |
| axon development |
| regulation of cell growth |
| morphogenesis of an epithelium |
| embryonic organ development |
| pattern specification process |
| positive regulation of neurogenesis |
| blood vessel development |
| regulation of cell morphogenesis |
| skeletal system development |
| regulation of neuron projection development |
| cellular response to growth factor stimulus |
| vasculature development |
| regulation of anatomical structure size |
| cardiovascular system development |
| heart development |
| response to growth factor |
| positive regulation of nervous system development |
| positive regulation of cellular component movement |
| positive regulation of cell development |
| positive regulation of locomotion |
| tissue morphogenesis |
| embryonic morphogenesis |
| positive regulation of response to external stimulus |
| chordate embryonic development |
| embryo development ending in birth or egg hatching |
| tube morphogenesis |
| regulation of neuron differentiation |
| neuron projection development |
| regulation of growth |
| regulation of plasma membrane bounded cell projection organization |
| regulation of cell projection organization |
| enzyme linked receptor protein signaling pathway |
| calcium ion binding |
| neuron development |
| regulation of neurogenesis |
| tube development |
| circulatory system development |
| regulation of nervous system development |
| regulation of cell development |
| animal organ morphogenesis |
| cell migration |
| positive regulation of cell differentiation |
| embryo development |
| regulation of locomotion |
| regulation of cellular component movement |
| neuron differentiation |
| regulation of anatomical structure morphogenesis |
| localization of cell |
| cell motility |
| regulation of response to external stimulus |
| epithelium development |
| plasma membrane bounded cell projection organization |
| cell projection organization |
| positive regulation of cellular component organization |
| cellular response to endogenous stimulus |
| negative regulation of signal transduction |
| locomotion |
| negative regulation of cell communication |
| negative regulation of signaling |
| positive regulation of developmental process |
| response to endogenous stimulus |
| generation of neurons |
| movement of cell or subcellular component |
| negative regulation of response to stimulus |
| neurogenesis |
| cell development |
| positive regulation of multicellular organismal process |
| tissue development |
| regulation of cell differentiation |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| GW501516 25μM R06 exp285 | -1.72 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 3415
- Expression level (log2 read counts): 6.54
Expression Distribution
MEGF8 Expression in NALM6 Cells: 6.54
