MEIOB

Entrez Summary: N/A
UniProt Summary: Single-stranded DNA-binding protein required for homologous recombination in meiosis I. Required for double strand breaks (DSBs) repair and crossover formation and promotion of faithful and complete synapsis. Not required for the initial loading of recombinases but required to maintain a proper number of RAD51 and DMC1 foci after the zygotene stage. May act by ensuring the stabilization of recombinases, which is required for successful homology search and meiotic recombination. Displays Single-stranded DNA 3'-5' exonuclease activity in vitro (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

single-stranded DNA 3-5 exodeoxyribonuclease activity
female meiosis I
resolution of meiotic recombination intermediates
meiotic chromosome separation
male meiosis I
female meiotic nuclear division
chromosome separation
synapsis
male meiotic nuclear division
reciprocal meiotic recombination
homologous recombination
homologous chromosome segregation
chromosome organization involved in meiotic cell cycle
meiotic chromosome segregation
double-strand break repair via homologous recombination
recombinational repair
single-stranded DNA binding
meiosis I
meiosis I cell cycle process
chromosome
female gamete generation
meiotic nuclear division
meiotic cell cycle process
fertilization
double-strand break repair
nuclear chromosome segregation
DNA recombination
meiotic cell cycle
chromosome segregation
nuclear division
nucleic acid phosphodiester bond hydrolysis
organelle fission
cellular process involved in reproduction in multicellular organism
chromatin binding
DNA repair
male gamete generation
gamete generation
DNA metabolic process
cellular response to DNA damage stimulus
multicellular organismal reproductive process