MEIS1 [The Human Chemical-Genetic Interaction Map Project]

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======= MEIS1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MEIS1
  * **<color #00a2e8>Official Name</color>**: Meis homeobox 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4211|4211]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O00470|O00470]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MEIS1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MEIS1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601739|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Homeobox genes, of which the most well-characterized category is represented by the HOX genes, play a crucial role in normal development. In addition, several homeoproteins are involved in neoplasia. This gene encodes a homeobox protein belonging to the TALE ('three amino acid loop extension') family of homeodomain-containing proteins. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Acts as a transcriptional regulator of PAX6. Acts as a transcriptional activator of PF4 in complex with PBX1 or PBX2. Required for hematopoiesis, megakaryocyte lineage development and vascular patterning. May function as a cofactor for HOXA7 and HOXA9 in the induction of myeloid leukemias. {ECO:0000269|PubMed:12609849}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Homeobox KN|
|Homeobox|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of cardiac muscle cell proliferation|
|megakaryocyte development|
|definitive hemopoiesis|
|megakaryocyte differentiation|
|lens morphogenesis in camera-type eye|
|negative regulation of heart growth|
|negative regulation of cardiac muscle tissue growth|
|bone cell development|
|negative regulation of organ growth|
|negative regulation of cardiac muscle tissue development|
|regulation of cardiac muscle cell proliferation|
|negative regulation of striated muscle tissue development|
|negative regulation of muscle organ development|
|negative regulation of muscle tissue development|
|regulation of cardiac muscle tissue growth|
|myeloid cell development|
|regulation of heart growth|
|negative regulation of myeloid cell differentiation|
|lens development in camera-type eye|
|regulation of cardiac muscle tissue development|
|regulation of organ growth|
|negative regulation of developmental growth|
|camera-type eye morphogenesis|
|regulation of striated muscle tissue development|
|regulation of muscle tissue development|
|regulation of muscle organ development|
|negative regulation of hemopoiesis|
|eye morphogenesis|
|locomotory behavior|
|bone development|
|transcription factor complex|
|myeloid cell differentiation|
|negative regulation of neuron differentiation|
|regulation of myeloid cell differentiation|
|negative regulation of growth|
|sensory organ morphogenesis|
|negative regulation of neurogenesis|
|negative regulation of nervous system development|
|camera-type eye development|
|angiogenesis|
|regulation of developmental growth|
|negative regulation of cell development|
|eye development|
|visual system development|
|sensory system development|
|chromatin binding|
|blood vessel morphogenesis|
|negative regulation of immune system process|
|DNA-binding transcription activator activity, RNA polymerase II-specific|
|regulation of hemopoiesis|
|blood vessel development|
|protein heterodimerization activity|
|skeletal system development|
|RNA polymerase II proximal promoter sequence-specific DNA binding|
|vasculature development|
|cardiovascular system development|
|sensory organ development|
|hemopoiesis|
|behavior|
|hematopoietic or lymphoid organ development|
|immune system development|
|tube morphogenesis|
|regulation of neuron differentiation|
|regulation of growth|
|negative regulation of cell population proliferation|
|negative regulation of cell differentiation|
|regulation of neurogenesis|
|tube development|
|circulatory system development|
|anatomical structure formation involved in morphogenesis|
|regulation of nervous system development|
|regulation of cell development|
|negative regulation of developmental process|
|animal organ morphogenesis|
|negative regulation of multicellular organismal process|
|positive regulation of transcription by RNA polymerase II|
|DNA binding|
|generation of neurons|
|positive regulation of transcription, DNA-templated|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|regulation of cell population proliferation|
|neurogenesis|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|cell development|
|regulation of immune system process|
|positive regulation of RNA metabolic process|
|regulation of cell differentiation|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp288|HMS-I2 10μM R06 exp288]]|-1.86|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rrm1|RRM1]]|0.408|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14840
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.33 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MEIS1 Expression in NALM6 Cells: 0.33'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>