MEIS1

Entrez Summary: Homeobox genes, of which the most well-characterized category is represented by the HOX genes, play a crucial role in normal development. In addition, several homeoproteins are involved in neoplasia. This gene encodes a homeobox protein belonging to the TALE ('three amino acid loop extension') family of homeodomain-containing proteins. [provided by RefSeq, Jul 2008].
UniProt Summary: Acts as a transcriptional regulator of PAX6. Acts as a transcriptional activator of PF4 in complex with PBX1 or PBX2. Required for hematopoiesis, megakaryocyte lineage development and vascular patterning. May function as a cofactor for HOXA7 and HOXA9 in the induction of myeloid leukemias. {ECO:0000269|PubMed:12609849}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Homeobox KN
Homeobox

negative regulation of cardiac muscle cell proliferation
megakaryocyte development
definitive hemopoiesis
megakaryocyte differentiation
lens morphogenesis in camera-type eye
negative regulation of heart growth
negative regulation of cardiac muscle tissue growth
bone cell development
negative regulation of organ growth
negative regulation of cardiac muscle tissue development
regulation of cardiac muscle cell proliferation
negative regulation of striated muscle tissue development
negative regulation of muscle organ development
negative regulation of muscle tissue development
regulation of cardiac muscle tissue growth
myeloid cell development
regulation of heart growth
negative regulation of myeloid cell differentiation
lens development in camera-type eye
regulation of cardiac muscle tissue development
regulation of organ growth
negative regulation of developmental growth
camera-type eye morphogenesis
regulation of striated muscle tissue development
regulation of muscle tissue development
regulation of muscle organ development
negative regulation of hemopoiesis
eye morphogenesis
locomotory behavior
bone development
transcription factor complex
myeloid cell differentiation
negative regulation of neuron differentiation
regulation of myeloid cell differentiation
negative regulation of growth
sensory organ morphogenesis
negative regulation of neurogenesis
negative regulation of nervous system development
camera-type eye development
angiogenesis