MEIS3

Entrez Summary: This gene encodes a homeobox protein and probable transcriptional regulator. The orthologous protein in mouse controls expression of 3-phosphoinositide dependent protein kinase 1, which promotes survival of pancreatic beta-cells. [provided by RefSeq, Sep 2016].
UniProt Summary: Transcriptional regulator which directly modulates PDPK1 expression, thus promoting survival of pancreatic beta-cells. Also regulates expression of NDFIP1, BNIP3, and CCNG1. {ECO:0000250|UniProtKB:P97368}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Docetaxel 0.002μM R01 exp45	-2.01
Pyrazinamide 100μM R08 exp516	-1.72
GSK-J5 1.5μM R08 exp484	1.8
Centrinone 0.5μM R07 exp343	1.84
Dorsomorphin 5μM R07 exp357	1.87
CyclicAMP 200μM R08 exp475	1.91
2-Methoxyestradiol 0.55 to 0.75μM on day4 R07 exp311	1.98
Tubastatin-A 2.5μM R07 exp417	2.06
IWR1 50μM R08 exp495	2.24
Calcium Ionophore 0.4μM R07 exp342	2.33

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Homeobox KN
Homeobox

positive regulation of protein kinase B signaling
regulation of protein kinase B signaling
negative regulation of apoptotic signaling pathway
chromatin binding
regulation of apoptotic signaling pathway
sequence-specific DNA binding
DNA-binding transcription activator activity, RNA polymerase II-specific
negative regulation of apoptotic process
negative regulation of programmed cell death
negative regulation of cell death
positive regulation of intracellular signal transduction
positive regulation of transcription by RNA polymerase II
negative regulation of signal transduction
negative regulation of cell communication
negative regulation of signaling
regulation of apoptotic process
positive regulation of transcription, DNA-templated
DNA-binding transcription factor activity, RNA polymerase II-specific
regulation of programmed cell death
negative regulation of response to stimulus
positive regulation of nucleic acid-templated transcription
positive regulation of RNA biosynthetic process
positive regulation of signal transduction
regulation of cell death
positive regulation of RNA metabolic process
positive regulation of cell communication
positive regulation of signaling
regulation of intracellular signal transduction
positive regulation of nucleobase-containing compound metabolic process
positive regulation of macromolecule biosynthetic process
positive regulation of cellular biosynthetic process
positive regulation of gene expression
positive regulation of biosynthetic process