MESP1 [The Human Chemical-Genetic Interaction Map Project]

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======= MESP1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MESP1
  * **<color #00a2e8>Official Name</color>**: mesoderm posterior bHLH transcription factor 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=55897|55897]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9BRJ9|Q9BRJ9]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MESP1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MESP1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/608689|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Transcription factor. Plays a role in the epithelialization of somitic mesoderm and in the development of cardiac mesoderm. Defines the rostrocaudal patterning of the somites by participating in distinct Notch pathways (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|HLH|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cardioblast migration|
|sinus venosus development|
|cardioblast migration to the midline involved in heart field formation|
|sinus venosus morphogenesis|
|positive regulation of hepatocyte differentiation|
|cell migration to the midline involved in heart development|
|cardioblast anterior-lateral migration|
|negative regulation of endodermal cell fate specification|
|cardiac atrium formation|
|regulation of heart induction by regulation of canonical Wnt signaling pathway|
|regulation of hepatocyte differentiation|
|regulation of endodermal cell fate specification|
|positive regulation of heart induction by negative regulation of canonical Wnt signaling pathway|
|cell migration involved in heart formation|
|sinoatrial node development|
|negative regulation of endodermal cell differentiation|
|sinoatrial node cell differentiation|
|cardiac cell fate determination|
|regulation of endodermal cell differentiation|
|negative regulation of mesodermal cell fate specification|
|growth involved in heart morphogenesis|
|negative regulation of mesoderm formation|
|negative regulation of mesodermal cell differentiation|
|regulation of Notch signaling pathway involved in heart induction|
|positive regulation of Notch signaling pathway involved in heart induction|
|cardiac pacemaker cell differentiation|
|negative regulation of Wnt signaling pathway involved in heart development|
|mesodermal cell migration|
|positive regulation of heart induction|
|regulation of heart induction|
|negative regulation of cell fate specification|
|convergent extension involved in organogenesis|
|regulation of Wnt signaling pathway involved in heart development|
|cardiac vascular smooth muscle cell differentiation|
|regulation of mesoderm formation|
|negative regulation of gastrulation|
|regulation of mesodermal cell differentiation|
|regulation of mesodermal cell fate specification|
|negative regulation of mesoderm development|
|heart field specification|
|secondary heart field specification|
|cardiac cell fate commitment|
|cardiac ventricle formation|
|cardiac chamber formation|
|cardiac conduction system development|
|lateral mesoderm development|
|regulation of cell fate specification|
|heart formation|
|negative regulation of cell fate commitment|
|cell migration involved in heart development|
|convergent extension|
|vascular smooth muscle cell differentiation|
|enhancer binding|
|specification of animal organ identity|
|regulation of mesoderm development|
|signal transduction involved in regulation of gene expression|
|negative regulation of embryonic development|
|heart growth|
|regulation of cell fate commitment|
|cardiac atrium morphogenesis|
|smooth muscle cell differentiation|
|animal organ formation|
|cardiac atrium development|
|regulation of animal organ formation|
|regulation of gastrulation|
|cell fate determination|
|regulation of heart morphogenesis|
|coronary vasculature development|
|positive regulation of Notch signaling pathway|
|positive regulation of striated muscle cell differentiation|
|positive regulation of epithelial cell differentiation|
|heart looping|
|somitogenesis|
|embryonic heart tube morphogenesis|
|determination of heart left/right asymmetry|
|mesoderm formation|
|mesoderm morphogenesis|
|cardiac ventricle morphogenesis|
|embryonic heart tube development|
|positive regulation of animal organ morphogenesis|
|endothelial cell differentiation|
|somite development|
|positive regulation of muscle cell differentiation|
|cardiac muscle cell differentiation|
|endothelium development|
|segmentation|
|organ growth|
|regulation of striated muscle cell differentiation|
|regulation of Notch signaling pathway|
|formation of primary germ layer|
|developmental growth involved in morphogenesis|
|cardiocyte differentiation|
|determination of left/right symmetry|
|determination of bilateral symmetry|
|mesoderm development|
|specification of symmetry|
|Notch signaling pathway|
|cardiac chamber morphogenesis|
|cardiac ventricle development|
|regulation of embryonic development|
|regulation of epithelial cell differentiation|
|regulation of muscle cell differentiation|
|gastrulation|
|protein dimerization activity|
|cardiac muscle tissue development|
|cardiac chamber development|
|ameboidal-type cell migration|
|negative regulation of canonical Wnt signaling pathway|
|striated muscle cell differentiation|
|negative regulation of Wnt signaling pathway|
|anterior/posterior pattern specification|
|transcription regulatory region DNA binding|
|mesenchyme development|
|muscle cell differentiation|
|cell fate commitment|
|heart morphogenesis|
|regulation of animal organ morphogenesis|
|regulation of canonical Wnt signaling pathway|
|striated muscle tissue development|
|embryonic organ morphogenesis|
|muscle tissue development|
|epithelial tube morphogenesis|
|regionalization|
|regulation of Wnt signaling pathway|
|developmental growth|
|growth|
|morphogenesis of an epithelium|
|embryonic organ development|
|pattern specification process|
|DNA-binding transcription activator activity, RNA polymerase II-specific|
|muscle structure development|
|blood vessel development|
|RNA polymerase II proximal promoter sequence-specific DNA binding|
|vasculature development|
|cardiovascular system development|
|heart development|
|tissue morphogenesis|
|embryonic morphogenesis|
|chordate embryonic development|
|embryo development ending in birth or egg hatching|
|tube morphogenesis|
|DNA-binding transcription factor activity|
|epithelial cell differentiation|
|negative regulation of cell differentiation|
|tube development|
|circulatory system development|
|anatomical structure formation involved in morphogenesis|
|negative regulation of developmental process|
|animal organ morphogenesis|
|cell migration|
|positive regulation of cell differentiation|
|embryo development|
|regulation of anatomical structure morphogenesis|
|cell motility|
|localization of cell|
|epithelium development|
|negative regulation of transcription, DNA-templated|
|negative regulation of multicellular organismal process|
|positive regulation of transcription by RNA polymerase II|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of signal transduction|
|locomotion|
|negative regulation of RNA metabolic process|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|movement of cell or subcellular component|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|negative regulation of response to stimulus|
|neurogenesis|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|positive regulation of signal transduction|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|tissue development|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|1.73|
|[[:results:exp199|Etoposide 0.3μM R05 exp199]]|1.86|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8783
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -1.14 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MESP1 Expression in NALM6 Cells: -1.14'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>